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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone and Men's Health Articles
High hematocrit prevalence with intranasal vs. intramuscular testosterone
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<blockquote data-quote="tareload" data-source="post: 183690"><p>Thanks very much again [USER=13851]@madman[/USER]. You are a machine.</p><p></p><p>[USER=38109]@Cataceous[/USER], I've thought quite a bit about this as once or twice weekly TC really does a number on my Hct.</p><p></p><p>From the paper above:</p><p></p><p></p><p></p><p>Reference 21:</p><p>[URL unfurl="true"]https://eje.bioscientifica.com/view/journals/eje/162/2/385.xml[/URL]</p><p></p><p>Seems to me you'd need something with a very short half life like Natesto or even the creams with crystalline testosterone (<a href="https://onlinelibrary.wiley.com/doi/pdf/10.1111/andr.12357" target="_blank">half life of hours</a>) to really get the benefit here on reduced Hct. </p><p></p><p>Let's say you are doing 80 mg per week either 1 weekly injection or breaking it up daily:</p><p></p><p>[ATTACH=full]10306[/ATTACH]</p><p></p><p>Either way your trough never drops below physiological. Although AUC invariant, seems like these papers indicate you need time under physiological test levels in order to reap the benefit on your Hct. If I remember correctly trying to trace back the kinetics of testosterone on hepcidin suppression and to EPO, it's first order and you'd reach saturation, so whether you do Test Ester once a day (weekly dosage / 7) or once weekly (weekly dosage / 1) you run into the same problem (trough never drops below physiologic range). To turn off hepcidin suppression and slow down erythropoiesis in an interval fashion, you have to drop test levels intermittently below where they activate the chemical cascade. </p><p></p><p>Thanks to you guys for bringing this up. Curious your thoughts.</p><p></p><p>There is seldom a free lunch, bummer.</p></blockquote><p></p>
[QUOTE="tareload, post: 183690"] Thanks very much again [USER=13851]@madman[/USER]. You are a machine. [USER=38109]@Cataceous[/USER], I've thought quite a bit about this as once or twice weekly TC really does a number on my Hct. From the paper above: Reference 21: [URL unfurl="true"]https://eje.bioscientifica.com/view/journals/eje/162/2/385.xml[/URL] Seems to me you'd need something with a very short half life like Natesto or even the creams with crystalline testosterone ([URL='https://onlinelibrary.wiley.com/doi/pdf/10.1111/andr.12357']half life of hours[/URL]) to really get the benefit here on reduced Hct. Let's say you are doing 80 mg per week either 1 weekly injection or breaking it up daily: [ATTACH type="full" alt="1596577899151.png"]10306[/ATTACH] Either way your trough never drops below physiological. Although AUC invariant, seems like these papers indicate you need time under physiological test levels in order to reap the benefit on your Hct. If I remember correctly trying to trace back the kinetics of testosterone on hepcidin suppression and to EPO, it's first order and you'd reach saturation, so whether you do Test Ester once a day (weekly dosage / 7) or once weekly (weekly dosage / 1) you run into the same problem (trough never drops below physiologic range). To turn off hepcidin suppression and slow down erythropoiesis in an interval fashion, you have to drop test levels intermittently below where they activate the chemical cascade. Thanks to you guys for bringing this up. Curious your thoughts. There is seldom a free lunch, bummer. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone and Men's Health Articles
High hematocrit prevalence with intranasal vs. intramuscular testosterone
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