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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
High Free T. but Regular T levels?
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<blockquote data-quote="madman" data-source="post: 200801" data-attributes="member: 13851"><p>The most accurate assays for TT/estradiol/DHT would be (LC/MS-MS) and Free Testosterone would be the gold standard Equilibrium Dialysis or Ultrafiltration (next best).</p><p></p><p>When posting labs always include reference ranges and testing methods/assays if possible.</p><p></p><p>I am a fellow canuck and looking over what you posted then your labs were most likely done at Dynacare or Lifelabs.</p><p></p><p>What province do you reside in?</p><p></p><p>Canadian reference range units are in (nmol/L).</p><p></p><p>US reference range units are in (ng/dL).</p><p></p><p>Regarding estradiol, I have used the standard immunoassay in the past and fortunately, the estradiol sensitive (LC/MS-MS) has been available in my province (Ontario) through Dynacare for the past few years.</p><p></p><p>Yours was tested using the standard immunoassay which can overestimate especially in cases of high CRP which can skew results.</p><p></p><p>Unfortunately the estradiol sensitive (LC/MS-MS) is only available through Dynacare in Ontario.</p><p></p><p>Seeing as you are injecting 120mg T/week (60 mg every 3.5 days) when were labs drawn?</p><p></p><p>We always want to test at the true trough (the lowest point) just before the next injection).</p><p></p><p>Being nitpicky when injecting every 3.5 days (84 hrs between injections)</p><p></p><p>Keep in mind that although TT is important to know FT is what truly matters as it is the active unbound fraction of testosterone responsible for the positive effects.</p><p></p><p>Again the only way to know where your FT truly sits is to have it tested using the most accurate assays such as ED or UF otherwise you would need to rely on calculated methods.</p><p></p><p>Yours was most likely done using the linear law-of-mass action <em>cFTV </em>as the piss poor direct immunoassay is no longer used and access to the gold standard Equilibrium Dialysis or Ultrafiltration is not readily available to everyone.</p><p></p><p>Although your TT 20 nmol/L (576 ng/dL) is far from high your FT would most likely be descent and if these are trough levels then the peak will be much higher.</p><p></p><p>We always need to keep peak/trough in mind when following a protocol (dose of T used/injection frequency) as this will have a significant impact on the outcome!</p><p></p><p>SHBG is critical to know as it will have a significant impact on TT/FT let alone can dictate what injection frequency may suit you best.</p><p></p><p>Men with low/lowish SHBG do not need to run very high let alone absurdly high TT in order to achieve a healthy FT.</p><p></p><p>Men with low/lowish SHBG tend to do better injecting lower doses of T more frequently (daily or EOD).....it comes down to the individual.</p><p></p><p>With an absurdly low SHBG 11 nmol/L, you would most likely fair better injecting lower doses of T daily or EOD.</p><p></p><p>Most men on trt are injecting (once weekly, twice weekly (every 3.5 days), M/W/F, EOD, or daily) using 100-200 mg/week T and many can easily achieve a healthy let alone high or in many cases <u>absurdly high FT</u> injecting 100-150 mg/week.</p><p></p><p>Believe it or not, some men achieve great FT levels by injecting <100 mg/week.</p><p></p><p>Sure some men may need the higher end dose (200 mg/week) but it is far from common.</p><p></p><p></p><p></p><p></p><p><strong><em>*Running too high an FT can cause a majority of the issues one can run into when using exogenous testosterone!</em></strong></p></blockquote><p></p>
[QUOTE="madman, post: 200801, member: 13851"] The most accurate assays for TT/estradiol/DHT would be (LC/MS-MS) and Free Testosterone would be the gold standard Equilibrium Dialysis or Ultrafiltration (next best). When posting labs always include reference ranges and testing methods/assays if possible. I am a fellow canuck and looking over what you posted then your labs were most likely done at Dynacare or Lifelabs. What province do you reside in? Canadian reference range units are in (nmol/L). US reference range units are in (ng/dL). Regarding estradiol, I have used the standard immunoassay in the past and fortunately, the estradiol sensitive (LC/MS-MS) has been available in my province (Ontario) through Dynacare for the past few years. Yours was tested using the standard immunoassay which can overestimate especially in cases of high CRP which can skew results. Unfortunately the estradiol sensitive (LC/MS-MS) is only available through Dynacare in Ontario. Seeing as you are injecting 120mg T/week (60 mg every 3.5 days) when were labs drawn? We always want to test at the true trough (the lowest point) just before the next injection). Being nitpicky when injecting every 3.5 days (84 hrs between injections) Keep in mind that although TT is important to know FT is what truly matters as it is the active unbound fraction of testosterone responsible for the positive effects. Again the only way to know where your FT truly sits is to have it tested using the most accurate assays such as ED or UF otherwise you would need to rely on calculated methods. Yours was most likely done using the linear law-of-mass action [I]cFTV [/I]as the piss poor direct immunoassay is no longer used and access to the gold standard Equilibrium Dialysis or Ultrafiltration is not readily available to everyone. Although your TT 20 nmol/L (576 ng/dL) is far from high your FT would most likely be descent and if these are trough levels then the peak will be much higher. We always need to keep peak/trough in mind when following a protocol (dose of T used/injection frequency) as this will have a significant impact on the outcome! SHBG is critical to know as it will have a significant impact on TT/FT let alone can dictate what injection frequency may suit you best. Men with low/lowish SHBG do not need to run very high let alone absurdly high TT in order to achieve a healthy FT. Men with low/lowish SHBG tend to do better injecting lower doses of T more frequently (daily or EOD).....it comes down to the individual. With an absurdly low SHBG 11 nmol/L, you would most likely fair better injecting lower doses of T daily or EOD. Most men on trt are injecting (once weekly, twice weekly (every 3.5 days), M/W/F, EOD, or daily) using 100-200 mg/week T and many can easily achieve a healthy let alone high or in many cases [U]absurdly high FT[/U] injecting 100-150 mg/week. Believe it or not, some men achieve great FT levels by injecting <100 mg/week. Sure some men may need the higher end dose (200 mg/week) but it is far from common. [B][I]*Running too high an FT can cause a majority of the issues one can run into when using exogenous testosterone![/I][/B] [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
High Free T. but Regular T levels?
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