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General Health & Fitness
Nutrition and Supplements
High estradiol / Hematocrit: What supplements to avoid?
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<blockquote data-quote="lowe2sucks" data-source="post: 72145" data-attributes="member: 13891"><p><a href="https://www.excelmale.com/member.php?15131-FeelingLost" target="_blank">FeelingLost</a><span style="color: #3E3E3E"> I ve seen somebody did both e2 regular and e2 sensitive at same blood draw and the difference was pretty big.. so it's safe to say that e2 sensitive is needed for proper evaluation of bloodwork. if regular will say you are 20 points higher then sensitive e2 it's pretty big difference, you may think you need an AI when you actually don't and mess up your protocol</span></p><p><span style="color: #3E3E3E">by the way pregnenolone is not estrogenic</span></p><p><span style="color: #3E3E3E">infact it's estrogen antagonist (not agonist) and I can confirm it's anti estrogenic effects from personal experience</span></p><p><span style="color: #3E3E3E"></span><span style="color: #141414"><span style="font-family: 'Georgia'">"...</span></span><strong>As shown in Fig. 3, a 100-fold increase in oestradiol production was evident in cell culture containing FSH and testosterone during induction. All the other steroids were ineffective as substrates for aromatase. Similarly, during the test period the synthesis of oestradiol was significantly (p<0.05) enhanced in cells previously exposed to testosterone (160%) or DES (25%) and FSH, when compared with that of the FSH-stimulated ones. <span style="color: #ff0000">However, </span><span style="color: #ff0000"><strong>the presence of pregnenolone, progesterone and DHT (during the induction) significantly (p<0.05) decreased the FSH-induced aromatization of testosterone</strong>."</span></strong></p><p><strong><span style="color: #ff0000"></span></strong><span style="color: #141414"><span style="font-family: 'Georgia'">"...</span></span><strong>Estrogen is antagonized by Delta-5-pregnenolone (155) and by progesterone (156); the two have different effects on Plalypoecilus maculatus (157). <strong>Estrogen induces mating in spayed adrenalectomized rats (158). When given with progesterone, it induces endometrial hyperplasia in diabetics (159), but it causes an inconstant luteinizing reaction in ovaries of normal individuals (160). It <strong>produces changes in the human vaginal smear in the following order of effectiveness; stilbestrol, estrone, estriol</strong> (161)."</strong></strong></p><p><strong><strong></strong></strong></p><p><strong><strong><span style="color: #ff0000">In addition, pregenolone sulfate is capable of inhibiting both estrone-sulfatase and 17a-HSD, which are responsible for the synthesis of estrone and estradiol respectively. Pharma drugs that target inhibition of these two enzymes are in clinical trials for breast cancer.</span></strong></strong></p></blockquote><p></p>
[QUOTE="lowe2sucks, post: 72145, member: 13891"] [URL="https://www.excelmale.com/member.php?15131-FeelingLost"]FeelingLost[/URL][COLOR=#3E3E3E] I ve seen somebody did both e2 regular and e2 sensitive at same blood draw and the difference was pretty big.. so it's safe to say that e2 sensitive is needed for proper evaluation of bloodwork. if regular will say you are 20 points higher then sensitive e2 it's pretty big difference, you may think you need an AI when you actually don't and mess up your protocol by the way pregnenolone is not estrogenic infact it's estrogen antagonist (not agonist) and I can confirm it's anti estrogenic effects from personal experience [/COLOR][COLOR=#141414][FONT=Georgia]"...[/FONT][/COLOR][B]As shown in Fig. 3, a 100-fold increase in oestradiol production was evident in cell culture containing FSH and testosterone during induction. All the other steroids were ineffective as substrates for aromatase. Similarly, during the test period the synthesis of oestradiol was significantly (p<0.05) enhanced in cells previously exposed to testosterone (160%) or DES (25%) and FSH, when compared with that of the FSH-stimulated ones. [COLOR=#ff0000]However, [/COLOR][COLOR=#ff0000][B]the presence of pregnenolone, progesterone and DHT (during the induction) significantly (p<0.05) decreased the FSH-induced aromatization of testosterone[/B]." [/COLOR][/B][COLOR=#141414][FONT=Georgia]"...[/FONT][/COLOR][B]Estrogen is antagonized by Delta-5-pregnenolone (155) and by progesterone (156); the two have different effects on Plalypoecilus maculatus (157). [B]Estrogen induces mating in spayed adrenalectomized rats (158). When given with progesterone, it induces endometrial hyperplasia in diabetics (159), but it causes an inconstant luteinizing reaction in ovaries of normal individuals (160). It [B]produces changes in the human vaginal smear in the following order of effectiveness; stilbestrol, estrone, estriol[/B] (161)." [COLOR=#ff0000]In addition, pregenolone sulfate is capable of inhibiting both estrone-sulfatase and 17a-HSD, which are responsible for the synthesis of estrone and estradiol respectively. Pharma drugs that target inhibition of these two enzymes are in clinical trials for breast cancer.[/COLOR][/B][/B] [/QUOTE]
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High estradiol / Hematocrit: What supplements to avoid?
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