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I would not just blame it on the elevated estradiol as injecting larger doses of T (100 mg) once weekly will drive your up TT/FT/e2 levels and although high estradiol can have an inflammatory effect causing acne flare-ups T/DHT act upon the AR which can stimulate the sebaceous glands in the skin (increase the size of the sebaceous glands/increase sebum production) which can cause acne in the genetically prone.

The downfall of injecting larger doses of T once weekly is not only will there be a big difference in the peak--->trough as T levels will peak 8-24 hrs post-injection and be elevated during the first few days only to be much lower come weeks end (trough) which can have a negative impact on energy/mood/libido/erectile function/recovery let alone your blood levels will not be as stable throughout the week.

You would be far better off splitting the weekly dose (100 mg) into twice-weekly injections (50 mg every 3.5 days).

Regardless you are getting blood work done at the wrong time (4 days post-injection) as we want to know where your levels sit at true trough (lowest point) just before your next injection to see where said protocol (dose T/injection frequency) has your TT/FT/e2 levels.