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General Health & Fitness
Nutrition and Supplements
High doses Glycine + NAC supplementation improved body composition, health markers and aging in Older HIV patients
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<blockquote data-quote="sammmy" data-source="post: 231144" data-attributes="member: 38594"><p><h2>4. Discussion</h2><p>This study highlights the impact of GlyNAC supplementation on several key defects associated with premature aging in PWH (People with HIV). The salient findings are that: (1) Compared to age, gender and BMI-matched HIV uninfected controls, PWH had (a) GSH (Glutathione) deficiency and elevated OxS (Oxidative Stress); (b) impaired MFO and MGO; (c) abnormally low protein expression of key molecular regulators of energy-metabolism, autophagy and mitophagy; (d) cognitive impairment; (e) lower physical function; (f) elevated inflammation and endothelial dysfunction; (g) insulin resistance with elevated fasted glucose and insulin concentrations, but without an increase in fasting rates of gluconeogenesis, glycogenolysis, or glucose production; (h) higher total body fat, truncal fat, waist circumference, body weight, BMI, and blood pressure; (i) increased muscle protein breakdown; (2) GlyNAC supplementation for 12 weeks improved these defects; (3) Several accrued benefits receded 8 weeks after stopping GlyNAC. These findings could have implications for premature aging in PWH, and are discussed below.</p></blockquote><p></p>
[QUOTE="sammmy, post: 231144, member: 38594"] [HEADING=1]4. Discussion[/HEADING] This study highlights the impact of GlyNAC supplementation on several key defects associated with premature aging in PWH (People with HIV). The salient findings are that: (1) Compared to age, gender and BMI-matched HIV uninfected controls, PWH had (a) GSH (Glutathione) deficiency and elevated OxS (Oxidative Stress); (b) impaired MFO and MGO; (c) abnormally low protein expression of key molecular regulators of energy-metabolism, autophagy and mitophagy; (d) cognitive impairment; (e) lower physical function; (f) elevated inflammation and endothelial dysfunction; (g) insulin resistance with elevated fasted glucose and insulin concentrations, but without an increase in fasting rates of gluconeogenesis, glycogenolysis, or glucose production; (h) higher total body fat, truncal fat, waist circumference, body weight, BMI, and blood pressure; (i) increased muscle protein breakdown; (2) GlyNAC supplementation for 12 weeks improved these defects; (3) Several accrued benefits receded 8 weeks after stopping GlyNAC. These findings could have implications for premature aging in PWH, and are discussed below. [/QUOTE]
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General Health & Fitness
Nutrition and Supplements
High doses Glycine + NAC supplementation improved body composition, health markers and aging in Older HIV patients
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