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General Health & Fitness
Nutrition and Supplements
High doses Glycine + NAC supplementation improved body composition, health markers and aging in Older HIV patients
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<blockquote data-quote="sammmy" data-source="post: 231143" data-attributes="member: 38594"><p><h3>Body Composition</h3><p>PWH (People with HIV supplemented with Glycine+NAC) were matched to controls (that group was not supplemented) for body mass index (BMI), and hence there were no differences between the two groups at baseline for BMI, but PWH had significantly higher truncal fat (32% higher) and 9% higher waist-to-hip ratio suggesting greater central abdominal fat accumulation (<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7601820/table/biomedicines-08-00390-t008/" target="_blank">Table 8</a>; <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7601820/figure/biomedicines-08-00390-f007/" target="_blank">Figure 7</a>). After PWH received 12 weeks of GlyNAC supplementation there was a striking decline in BMI, total fat (decreased by 2.3 kg), truncal fat (decreased by 1.6 kg), waist circumference (decreased by 7.3 cm), and waist:hip ratio, and comparison with controls showed no significant differences in truncal fat (<em>p</em> = 0.07), waist circumference (<em>p</em> = 0.9), or WHR (<em>p</em> = 0.6). After stopping GlyNAC supplementation for 8 weeks, the waist circumference increased by 2.3%, and WHR increased 2.3%, suggesting that central fat tended to reaccumulate after GlyNAC withdrawal, but these values were lower than the pre-supplementation values suggesting the benefits of 12 w of GlyNAC supplementation on central fat persisted 8 w after stopping GlyNAC. There were no differences in lean mass between PWH and controls at baseline, and there were no significant changes with 12 w of GlyNAC supplementation. PWH had significantly higher systolic and diastolic blood pressure, which decreased significantly with GlyNAC. Although all participants had magnetic resonance spectroscopy scans to assess liver fat, only 2 participants had elevated liver fat at the basal scan, and the liver fat fraction decreased by 40% with GlyNAC supplementation.</p></blockquote><p></p>
[QUOTE="sammmy, post: 231143, member: 38594"] [HEADING=2]Body Composition[/HEADING] PWH (People with HIV supplemented with Glycine+NAC) were matched to controls (that group was not supplemented) for body mass index (BMI), and hence there were no differences between the two groups at baseline for BMI, but PWH had significantly higher truncal fat (32% higher) and 9% higher waist-to-hip ratio suggesting greater central abdominal fat accumulation ([URL='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7601820/table/biomedicines-08-00390-t008/']Table 8[/URL]; [URL='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7601820/figure/biomedicines-08-00390-f007/']Figure 7[/URL]). After PWH received 12 weeks of GlyNAC supplementation there was a striking decline in BMI, total fat (decreased by 2.3 kg), truncal fat (decreased by 1.6 kg), waist circumference (decreased by 7.3 cm), and waist:hip ratio, and comparison with controls showed no significant differences in truncal fat ([I]p[/I] = 0.07), waist circumference ([I]p[/I] = 0.9), or WHR ([I]p[/I] = 0.6). After stopping GlyNAC supplementation for 8 weeks, the waist circumference increased by 2.3%, and WHR increased 2.3%, suggesting that central fat tended to reaccumulate after GlyNAC withdrawal, but these values were lower than the pre-supplementation values suggesting the benefits of 12 w of GlyNAC supplementation on central fat persisted 8 w after stopping GlyNAC. There were no differences in lean mass between PWH and controls at baseline, and there were no significant changes with 12 w of GlyNAC supplementation. PWH had significantly higher systolic and diastolic blood pressure, which decreased significantly with GlyNAC. Although all participants had magnetic resonance spectroscopy scans to assess liver fat, only 2 participants had elevated liver fat at the basal scan, and the liver fat fraction decreased by 40% with GlyNAC supplementation. [/QUOTE]
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General Health & Fitness
Nutrition and Supplements
High doses Glycine + NAC supplementation improved body composition, health markers and aging in Older HIV patients
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