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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
High Dose HCG, Low Dose Testosterone
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<blockquote data-quote="xqfq" data-source="post: 163354" data-attributes="member: 38167"><p>Another possibility RE: E2, which I’ve maybe commented on here, is that HCG produces DHEA, which can turn into Androstenediol. This isn’t “E2” so it won’t show up on a blood test, but may create E2-like symptoms:</p><p></p><p>“<span style="color: rgb(34, 34, 34)"><span style="font-size: 16px">Androstenediol possesses potent </span></span><a href="https://en.m.wikipedia.org/wiki/Estrogen" target="_blank"><span style="color: rgb(107, 75, 161)"><span style="font-size: 16px">estrogenic</span></span></a><span style="color: rgb(34, 34, 34)"><span style="font-size: 16px">activity, similarly to DHEA and </span></span><a href="https://en.m.wikipedia.org/wiki/3%CE%B2-androstanediol" target="_blank"><span style="color: rgb(107, 75, 161)"><span style="font-size: 16px">3β-androstanediol</span></span></a><span style="color: rgb(34, 34, 34)"><span style="font-size: 16px">.</span></span>[SUP]<span style="color: rgb(34, 34, 34)"><a href="https://en.m.wikipedia.org/wiki/Androstenediol#cite_note-HackenbergTurgetto1993-2" target="_blank"><span style="color: rgb(107, 75, 161)">[2]</span></a></span>[/SUP]<span style="color: rgb(34, 34, 34)"><span style="font-size: 16px">It has approximately 6% and 17% of the </span></span><a href="https://en.m.wikipedia.org/wiki/Affinity_(pharmacology)" target="_blank"><span style="color: rgb(107, 75, 161)"><span style="font-size: 16px">affinity</span></span></a><span style="color: rgb(34, 34, 34)"><span style="font-size: 16px"> of estradiol at the </span></span><a href="https://en.m.wikipedia.org/wiki/ER%CE%B1" target="_blank"><span style="color: rgb(107, 75, 161)"><span style="font-size: 16px">ERα</span></span></a><span style="color: rgb(34, 34, 34)"><span style="font-size: 16px"> and </span></span><a href="https://en.m.wikipedia.org/wiki/ER%CE%B2" target="_blank"><span style="color: rgb(107, 75, 161)"><span style="font-size: 16px">ERβ</span></span></a><span style="color: rgb(34, 34, 34)"><span style="font-size: 16px">, respectively.</span></span>[SUP]<span style="color: rgb(34, 34, 34)"><a href="https://en.m.wikipedia.org/wiki/Androstenediol#cite_note-pmid9048584-3" target="_blank"><span style="color: rgb(107, 75, 161)">[3]</span></a></span>[/SUP]<span style="color: rgb(34, 34, 34)"><span style="font-size: 16px">Although androstenediol has far lower affinity for the ERs compared to the major estrogen </span></span><a href="https://en.m.wikipedia.org/wiki/Estradiol" target="_blank"><span style="color: rgb(107, 75, 161)"><span style="font-size: 16px">estradiol</span></span></a><span style="color: rgb(34, 34, 34)"><span style="font-size: 16px">, it circulates at approximately 100-fold higher concentrations, and so is thought may play a significant role as an estrogen in the body.</span></span>[SUP]<span style="color: rgb(34, 34, 34)"><a href="https://en.m.wikipedia.org/wiki/Androstenediol#cite_note-Bradbury2007-4" target="_blank"><span style="color: rgb(107, 75, 161)">[4]</span></a>”</span>[/SUP]</p><p></p><p>This is just a random guess though. No evidence as far as I can tell in terms of labs, data, etc. But if someone wants to dig in more it might be a good starting place.</p><p></p><p>For me, higher dose HCG hasn’t worked great because HCG is so..tricky. It varies so much in potency between vials and the phase of the mood that I never felt consistent when I was getting a lot of testosterone production from HCG.</p><p></p><p>It’s also almost impossible to travel with which is a big deal for me. Doesn’t matter much if you’re not getting a lot of your hormones from HCG, but if you are then it might suck.</p></blockquote><p></p>
[QUOTE="xqfq, post: 163354, member: 38167"] Another possibility RE: E2, which I’ve maybe commented on here, is that HCG produces DHEA, which can turn into Androstenediol. This isn’t “E2” so it won’t show up on a blood test, but may create E2-like symptoms: “[FONT=-apple-system][COLOR=rgb(34, 34, 34)][SIZE=16px]Androstenediol possesses potent [/SIZE][/COLOR][/FONT][URL='https://en.m.wikipedia.org/wiki/Estrogen'][COLOR=rgb(107, 75, 161)][FONT=-apple-system][SIZE=16px]estrogenic[/SIZE][/FONT][/COLOR][/URL][FONT=-apple-system][COLOR=rgb(34, 34, 34)][SIZE=16px]activity, similarly to DHEA and [/SIZE][/COLOR][/FONT][URL='https://en.m.wikipedia.org/wiki/3%CE%B2-androstanediol'][COLOR=rgb(107, 75, 161)][FONT=-apple-system][SIZE=16px]3β-androstanediol[/SIZE][/FONT][/COLOR][/URL][FONT=-apple-system][COLOR=rgb(34, 34, 34)][SIZE=16px].[/SIZE][/COLOR][/FONT][SUP][COLOR=rgb(34, 34, 34)][FONT=-apple-system][URL='https://en.m.wikipedia.org/wiki/Androstenediol#cite_note-HackenbergTurgetto1993-2'][COLOR=rgb(107, 75, 161)][FONT=inherit][2][/FONT][/COLOR][/URL][/FONT][/COLOR][/SUP][FONT=-apple-system][COLOR=rgb(34, 34, 34)][SIZE=16px]It has approximately 6% and 17% of the [/SIZE][/COLOR][/FONT][URL='https://en.m.wikipedia.org/wiki/Affinity_(pharmacology)'][COLOR=rgb(107, 75, 161)][FONT=-apple-system][SIZE=16px]affinity[/SIZE][/FONT][/COLOR][/URL][FONT=-apple-system][COLOR=rgb(34, 34, 34)][SIZE=16px] of estradiol at the [/SIZE][/COLOR][/FONT][URL='https://en.m.wikipedia.org/wiki/ER%CE%B1'][COLOR=rgb(107, 75, 161)][FONT=-apple-system][SIZE=16px]ERα[/SIZE][/FONT][/COLOR][/URL][FONT=-apple-system][COLOR=rgb(34, 34, 34)][SIZE=16px] and [/SIZE][/COLOR][/FONT][URL='https://en.m.wikipedia.org/wiki/ER%CE%B2'][COLOR=rgb(107, 75, 161)][FONT=-apple-system][SIZE=16px]ERβ[/SIZE][/FONT][/COLOR][/URL][FONT=-apple-system][COLOR=rgb(34, 34, 34)][SIZE=16px], respectively.[/SIZE][/COLOR][/FONT][SUP][COLOR=rgb(34, 34, 34)][FONT=-apple-system][URL='https://en.m.wikipedia.org/wiki/Androstenediol#cite_note-pmid9048584-3'][COLOR=rgb(107, 75, 161)][FONT=inherit][3][/FONT][/COLOR][/URL][/FONT][/COLOR][/SUP][FONT=-apple-system][COLOR=rgb(34, 34, 34)][SIZE=16px]Although androstenediol has far lower affinity for the ERs compared to the major estrogen [/SIZE][/COLOR][/FONT][URL='https://en.m.wikipedia.org/wiki/Estradiol'][COLOR=rgb(107, 75, 161)][FONT=-apple-system][SIZE=16px]estradiol[/SIZE][/FONT][/COLOR][/URL][FONT=-apple-system][COLOR=rgb(34, 34, 34)][SIZE=16px], it circulates at approximately 100-fold higher concentrations, and so is thought may play a significant role as an estrogen in the body.[/SIZE][/COLOR][/FONT][SUP][COLOR=rgb(34, 34, 34)][FONT=-apple-system][URL='https://en.m.wikipedia.org/wiki/Androstenediol#cite_note-Bradbury2007-4'][COLOR=rgb(107, 75, 161)][FONT=inherit][4][/FONT][/COLOR][/URL]”[/FONT][/COLOR][/SUP] This is just a random guess though. No evidence as far as I can tell in terms of labs, data, etc. But if someone wants to dig in more it might be a good starting place. For me, higher dose HCG hasn’t worked great because HCG is so..tricky. It varies so much in potency between vials and the phase of the mood that I never felt consistent when I was getting a lot of testosterone production from HCG. It’s also almost impossible to travel with which is a big deal for me. Doesn’t matter much if you’re not getting a lot of your hormones from HCG, but if you are then it might suck. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
High Dose HCG, Low Dose Testosterone
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