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General Health & Fitness
Nutrition and Supplements
High-dose biotin supplement can interfere with common laboratory tests
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<blockquote data-quote="Nelson Vergel" data-source="post: 57773" data-attributes="member: 3"><p>This case illustrates serious interference with some thyroid immunoassay tests by high-dose biotin ingestion resulting in the false diagnosis of severe thyrotoxicosis. Excess biotin can cause misleading test results — low creatine phosphokinase in acute coronary syndrome, negative human chorionic gonadotropin in ectopic pregnancy, low adrenocorticotropic hormone and high cortisol in Addison’s crisis, low TSH and high free thyroxine in myxedema coma — profoundly affecting medical decision making. In this case, incongruity of normal total T4 with elevated free T4 and free triiodothyronine suggested a laboratory artifact sparing further consumption of health care resources.</p><p></p><p><a href="http://www.healio.com/endocrinology/thyroid/news/print/endocrine-today/%7B0ff7371d-93a3-4865-b502-60fde9c98122%7D/high-dose-biotin-supplement-can-interfere-with-common-laboratory-tests?utm_source=maestro&utm_medium=email&utm_campaign=endocrinology%20news" target="_blank">http://www.healio.com/endocrinology/thyroid/news/print/endocrine-today/{0ff7371d-93a3-4865-b502-60fde9c98122}/high-dose-biotin-supplement-can-interfere-with-common-laboratory-tests?utm_source=maestro&utm_medium=email&utm_campaign=endocrinology news</a></p></blockquote><p></p>
[QUOTE="Nelson Vergel, post: 57773, member: 3"] This case illustrates serious interference with some thyroid immunoassay tests by high-dose biotin ingestion resulting in the false diagnosis of severe thyrotoxicosis. Excess biotin can cause misleading test results — low creatine phosphokinase in acute coronary syndrome, negative human chorionic gonadotropin in ectopic pregnancy, low adrenocorticotropic hormone and high cortisol in Addison’s crisis, low TSH and high free thyroxine in myxedema coma — profoundly affecting medical decision making. In this case, incongruity of normal total T4 with elevated free T4 and free triiodothyronine suggested a laboratory artifact sparing further consumption of health care resources. [url]http://www.healio.com/endocrinology/thyroid/news/print/endocrine-today/%7B0ff7371d-93a3-4865-b502-60fde9c98122%7D/high-dose-biotin-supplement-can-interfere-with-common-laboratory-tests?utm_source=maestro&utm_medium=email&utm_campaign=endocrinology%20news[/url] [/QUOTE]
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General Health & Fitness
Nutrition and Supplements
High-dose biotin supplement can interfere with common laboratory tests
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