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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
Hematocrit drives Blood Viscosity- Does that Matter in Men on TRT? Effect of Altitude?
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<blockquote data-quote="tareload" data-source="post: 142943"><p>Thanks for your question. Look at post #2 with fig. 2. What are the compensatory mechanisms shown in the flow chart after viscosity increases? Either blood pressure increases or ... blood vessels dilate. How much your body is capable of vasodilation is a function of a bunch of stuff including health of your blood vessel lining, age, genes, more complicated stuff.</p><p></p><p>Why did I mention losartan (Blood pressure drug) above? That's what it does, reduce blood pressure more when your body can't on its own by blockading the renin-angiotensin system (<em>See all of the posts around losartan and hematocrit on this site</em>)! So when you have experienced elevated hematocrit above range (what's your margin of safety?), you've got some decisions to make. Reduce your TRT dosage, give blood (which gets into a whole other topic on iron status), BP medication, other NO manipulation. Losartan has been demonstrated to lower hematocrit but now you are getting into polypharmacy and the tradeoffs associated. See all of the posts here at ExcelMale on losartan. Very few free lunches out there. That brings up another question for folks, anyone seen results with hematocrit reduction using 25-50 mg / day of losartan while on TRT (after reaching some type of pseudo steady-state)?</p><p></p><p>P.S.: Some additional fun reading I don't see discussed regularly by folks who say clinically relevant hematocrit elevation is no biggie. Nothing to see here, move along...<img src="data:image/gif;base64,R0lGODlhAQABAIAAAAAAAP///yH5BAEAAAAALAAAAAABAAEAAAIBRAA7" class="smilie smilie--sprite smilie--sprite1" alt=":)" title="Smile :)" loading="lazy" data-shortname=":)" />. Can you see what this trend in the paper below has to do with the observations shared by folks in this thread?</p><p></p><p><a href="https://www.ncbi.nlm.nih.gov/pubmed/16186121" target="_blank">Nitric oxide scavenging by red blood cells as a function of hematocrit and oxygenation</a></p></blockquote><p></p>
[QUOTE="tareload, post: 142943"] Thanks for your question. Look at post #2 with fig. 2. What are the compensatory mechanisms shown in the flow chart after viscosity increases? Either blood pressure increases or ... blood vessels dilate. How much your body is capable of vasodilation is a function of a bunch of stuff including health of your blood vessel lining, age, genes, more complicated stuff. Why did I mention losartan (Blood pressure drug) above? That's what it does, reduce blood pressure more when your body can't on its own by blockading the renin-angiotensin system ([I]See all of the posts around losartan and hematocrit on this site[/I])! So when you have experienced elevated hematocrit above range (what's your margin of safety?), you've got some decisions to make. Reduce your TRT dosage, give blood (which gets into a whole other topic on iron status), BP medication, other NO manipulation. Losartan has been demonstrated to lower hematocrit but now you are getting into polypharmacy and the tradeoffs associated. See all of the posts here at ExcelMale on losartan. Very few free lunches out there. That brings up another question for folks, anyone seen results with hematocrit reduction using 25-50 mg / day of losartan while on TRT (after reaching some type of pseudo steady-state)? P.S.: Some additional fun reading I don't see discussed regularly by folks who say clinically relevant hematocrit elevation is no biggie. Nothing to see here, move along...:). Can you see what this trend in the paper below has to do with the observations shared by folks in this thread? [URL='https://www.ncbi.nlm.nih.gov/pubmed/16186121']Nitric oxide scavenging by red blood cells as a function of hematocrit and oxygenation[/URL] [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
Hematocrit drives Blood Viscosity- Does that Matter in Men on TRT? Effect of Altitude?
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