Assuming (big assumption) altitude adaptation has similar time constant to TRT induced erythrocytosis, this reference may be of interest:
[URL unfurl="true"]https://pubmed.ncbi.nlm.nih.gov/18204195/[/URL]
High altitude adaptation is altitude and time dependent, following the simplified equation: Adaptation=Time/Altitude where High altitude adaptation factor=Time at altitude (days)/Altitude in kilometers (km). A complete and optimal hematocrit adaptation is only achieved at around 40 days for a subject going from sea level to 3510 m in La Paz. The time in days required to achieve full adaptation to any altitude, ascending from sea level, can be calculated by multiplying the adaptation factor of 11.4 times the altitude in km. Descending from high altitude in La Paz to sea level in Copenhagen, the hematocrit response is a linear fall over 18 to 23 days.
Notice the rapid Hct descent noted upon returning to sea level. I am not aware of similar study for TRT patients.
