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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
Hematocrit and TRT. How to have balance.
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<blockquote data-quote="Blackhawk" data-source="post: 238757" data-attributes="member: 16042"><p>Don't confuse the time it takes for HCT to DECREASE from dose reduction with the time it takes to INCREASE after a phlebotomy, they are entirely different.</p><p></p><p>The decrease is from attrition of red blood cells, i.e. natural cell death at the end of their life span.</p><p></p><p>The increase is from erythopoesis which is called for by the Kidneys releasing EPO, and held in check by hepcidin. EPO increases due to hypoxemia, so any time the set point (HCT/HGB levels) is not met, they crank into high gear and production can increase quite dynamically. This does not take months. It happens rapidly. A well documented example, RBC, HG and HCT increase significantly in about 6 days as adaptation to lower blood oxygenation when a human goes to significantly higher altitude. </p><p></p><p>Testosterone inhibits hepcidin, and when that brake is released more RBCs are produced. The erythropoetic stem cells normally crank out roughly 292 million red cells per second (by one simple mathematical model), and much more is possible when EPO increased and hepcidin is inhibited.</p><p></p><p>If you have a problem from taking steroids, your body's set point has changed. Hepcidin is inhibited, and EPO can rise. Those factors have nothing to do with how long it takes red cells to die after they are intially created, only what the regulation system senses. If it expects a HCT of 55, and a unit of blood is removed, and plasma volume recovers. it in effect will try to make up for the loss quickly. That adaptive process is non linear. Every person's body will react to this according to it's own dynamics.</p></blockquote><p></p>
[QUOTE="Blackhawk, post: 238757, member: 16042"] Don't confuse the time it takes for HCT to DECREASE from dose reduction with the time it takes to INCREASE after a phlebotomy, they are entirely different. The decrease is from attrition of red blood cells, i.e. natural cell death at the end of their life span. The increase is from erythopoesis which is called for by the Kidneys releasing EPO, and held in check by hepcidin. EPO increases due to hypoxemia, so any time the set point (HCT/HGB levels) is not met, they crank into high gear and production can increase quite dynamically. This does not take months. It happens rapidly. A well documented example, RBC, HG and HCT increase significantly in about 6 days as adaptation to lower blood oxygenation when a human goes to significantly higher altitude. Testosterone inhibits hepcidin, and when that brake is released more RBCs are produced. The erythropoetic stem cells normally crank out roughly 292 million red cells per second (by one simple mathematical model), and much more is possible when EPO increased and hepcidin is inhibited. If you have a problem from taking steroids, your body's set point has changed. Hepcidin is inhibited, and EPO can rise. Those factors have nothing to do with how long it takes red cells to die after they are intially created, only what the regulation system senses. If it expects a HCT of 55, and a unit of blood is removed, and plasma volume recovers. it in effect will try to make up for the loss quickly. That adaptive process is non linear. Every person's body will react to this according to it's own dynamics. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
Hematocrit and TRT. How to have balance.
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