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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Help with protocol
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<blockquote data-quote="madman" data-source="post: 193476" data-attributes="member: 13851"><p>Although your trough TT may seem subpar seeing as your SHBG is very low 11 nmol/L then your FT should be descent and keep in mind that your peak (8-12 hrs) post-injection will be much higher.</p><p></p><p>Top it off that we have no idea what testing method was used for TT/FT/e2 and you left out the reference ranges.</p><p></p><p>The most accurate assays would be TT/e2 (LC/MS-MS) and FT (ED or UF).</p><p></p><p>Although TT is important to know you should be more concerned with FT as it is the active unbound fraction of testosterone responsible for the beneficial effects.</p><p></p><p>It is critical to have it tested using the most accurate assays.</p><p></p><p>Unfortunately many tend to use/rely on the piss poor direct immunoassay or calculated linear law-of-mass action which can over/underestimate.</p><p></p><p>To truly know where your FT sits on such protocol (dose T/injection frequency) you would need to have it tested using the most accurate assays such as the gold standard Equilibrium Dialysis or Ultrafiltration (next best).</p><p></p><p>The most important thing is you stated you feel okay and although your FT levels may still be descent due to your low SHBG you may have room to bring it up but again we have no idea what testing method was used let alone reference range.</p><p></p><p>If you did not have your FT tested by Equilibrium Dialysis or Ultrafiltration then I would have it retested before jumping to any conclusions.</p><p></p><p>With an SHBG of 11 nmol/L, you will not need a very high trough TT to attain a robust FT level.</p><p></p><p>You would most likely do better-injecting EOD or daily but again you need to know where your FT level truly sits on your current protocol.</p></blockquote><p></p>
[QUOTE="madman, post: 193476, member: 13851"] Although your trough TT may seem subpar seeing as your SHBG is very low 11 nmol/L then your FT should be descent and keep in mind that your peak (8-12 hrs) post-injection will be much higher. Top it off that we have no idea what testing method was used for TT/FT/e2 and you left out the reference ranges. The most accurate assays would be TT/e2 (LC/MS-MS) and FT (ED or UF). Although TT is important to know you should be more concerned with FT as it is the active unbound fraction of testosterone responsible for the beneficial effects. It is critical to have it tested using the most accurate assays. Unfortunately many tend to use/rely on the piss poor direct immunoassay or calculated linear law-of-mass action which can over/underestimate. To truly know where your FT sits on such protocol (dose T/injection frequency) you would need to have it tested using the most accurate assays such as the gold standard Equilibrium Dialysis or Ultrafiltration (next best). The most important thing is you stated you feel okay and although your FT levels may still be descent due to your low SHBG you may have room to bring it up but again we have no idea what testing method was used let alone reference range. If you did not have your FT tested by Equilibrium Dialysis or Ultrafiltration then I would have it retested before jumping to any conclusions. With an SHBG of 11 nmol/L, you will not need a very high trough TT to attain a robust FT level. You would most likely do better-injecting EOD or daily but again you need to know where your FT level truly sits on your current protocol. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Help with protocol
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