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Testosterone Replacement, Low T, HCG, & Beyond
Blood Test Discussion
Help w/ labs and my E2
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<blockquote data-quote="madman" data-source="post: 193024" data-attributes="member: 13851"><p><h4>[URL unfurl="true"]https://www.excelmale.com/forum/threads/very-low-e2-levels-during-menopause-complicate-assay-use-measurement.22484/[/URL]</h4><h4></h4><h4><strong>Need for standardization</strong></h4><p>Laboratory measurements are the sole source of information for diagnosis and treatment of many endocrine diseases, and hormone tests must be accurate and precise, according to Hubert W. Vesper, Ph.D., director of clinical standardization programs at the CDC’s National Center for Environmental Health.<strong> <u>Measurements of testosterone and estradiol are two of eight laboratory measurements the CDC has worked to optimize for high accuracy and precision</u>.</strong> Vesper said<strong> <u>reference intervals for estradiol and other hormones are needed, especially for postmenopausal women</u>.</strong></p><p><strong></strong></p><p><strong>“<u>One of the main challenges with measuring low-level sex steroids is analytical specificity and sensitivity, for example, making sure that an assay measures only estradiol or testosterone and no other compound</u>,” </strong>Vesper told <em>Endocrine Today</em>. <strong>“<u>The CDC’s Clinical Standardization Programs for estradiol and testosterone are assessing the measurement accuracy and reliability of estradiol and testosterone measurements, among other biomarkers</u>. <u>Those laboratories and assay manufacturers successfully participating in these CDC programs are listed on the CDC website</u>.”</strong></p><p><strong></strong></p><p><strong><u>If an assay manufacturer is listed on the CDC website, this means the assay is appropriately calibrated and one can see how well an assay determines these hormones in individual blood samples</u>,</strong> Vesper said.</p><p></p><p><strong>“<u>The higher the individual sample pass rate, the less inaccurate measurements are on different individual blood samples,”</u> </strong>Vesper said.<strong> “<u>In other words, the individual sample pass rate provides some information about the specificity of an assay</u>.”</strong></p><p></p><p>The Endocrine Society has been actively involved with the CDC in the effort to standardize assays for more accurate hormone measurement, Wierman said.</p><p></p><p><strong>“<u>One mass spectrometry assay is not the same as another mass spectrometry assay</u>,” </strong>Wierman said.<strong> “<u>Mass spectrometry is not perfect</u>. </strong><u><strong>There still are some very sensitive immunoassays, for example, for estradiol, that actually is very go</strong></u><strong><u>od</u>. <u>There are situations where they are useful</u>.”</strong></p><p></p><p>Vesper noted that some laboratories and assay manufacturers perform extra steps to ensure and improve the quality of hormone assays by voluntarily participating in the CDC’s clinical standardization programs or by participating in accuracy-based surveys offered by the College of American Pathologists.</p><p></p><p><strong>“<u>It is important to support laboratories with these efforts, as standardized, high-quality measurements will improve patient care</u>,” </strong>Vesper said.</p></blockquote><p></p>
[QUOTE="madman, post: 193024, member: 13851"] [HEADING=3][URL unfurl="true"]https://www.excelmale.com/forum/threads/very-low-e2-levels-during-menopause-complicate-assay-use-measurement.22484/[/URL][/HEADING] [HEADING=3][/HEADING] [HEADING=3][B]Need for standardization[/B][/HEADING] Laboratory measurements are the sole source of information for diagnosis and treatment of many endocrine diseases, and hormone tests must be accurate and precise, according to Hubert W. Vesper, Ph.D., director of clinical standardization programs at the CDC’s National Center for Environmental Health.[B] [U]Measurements of testosterone and estradiol are two of eight laboratory measurements the CDC has worked to optimize for high accuracy and precision[/U].[/B] Vesper said[B] [U]reference intervals for estradiol and other hormones are needed, especially for postmenopausal women[/U]. “[U]One of the main challenges with measuring low-level sex steroids is analytical specificity and sensitivity, for example, making sure that an assay measures only estradiol or testosterone and no other compound[/U],” [/B]Vesper told [I]Endocrine Today[/I]. [B]“[U]The CDC’s Clinical Standardization Programs for estradiol and testosterone are assessing the measurement accuracy and reliability of estradiol and testosterone measurements, among other biomarkers[/U]. [U]Those laboratories and assay manufacturers successfully participating in these CDC programs are listed on the CDC website[/U].” [U]If an assay manufacturer is listed on the CDC website, this means the assay is appropriately calibrated and one can see how well an assay determines these hormones in individual blood samples[/U],[/B] Vesper said. [B]“[U]The higher the individual sample pass rate, the less inaccurate measurements are on different individual blood samples,”[/U] [/B]Vesper said.[B] “[U]In other words, the individual sample pass rate provides some information about the specificity of an assay[/U].”[/B] The Endocrine Society has been actively involved with the CDC in the effort to standardize assays for more accurate hormone measurement, Wierman said. [B]“[U]One mass spectrometry assay is not the same as another mass spectrometry assay[/U],” [/B]Wierman said.[B] “[U]Mass spectrometry is not perfect[/U]. [/B][U][B]There still are some very sensitive immunoassays, for example, for estradiol, that actually is very go[/B][/U][B][U]od[/U]. [U]There are situations where they are useful[/U].”[/B] Vesper noted that some laboratories and assay manufacturers perform extra steps to ensure and improve the quality of hormone assays by voluntarily participating in the CDC’s clinical standardization programs or by participating in accuracy-based surveys offered by the College of American Pathologists. [B]“[U]It is important to support laboratories with these efforts, as standardized, high-quality measurements will improve patient care[/U],” [/B]Vesper said. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Blood Test Discussion
Help w/ labs and my E2
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