Comes down to the minimum weekly dose needed in order to stimulate maximum ITT (intratesticular testosterone)!
500 IU whether injected once weekly or split into more frequent injection is most likely too low a weekly dose to derive the maximum benefits!
If anything I would be aiming for 250 IU 3X weekly or better yet 500 IU 2-3X weekly.
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As you should know the only way to minimize/prevent testicular atrophy let alone maintain fertility when on exogenous T would be through the use of hCG or hCG + FSH unless you plan on using T formulations which will have the least impact such as nasal T-gel or you could throw oral TU (Kyzatrex) in there too!
Catch 22 here is when adding hCG to TTh depending on the dose used not only will it drive up your TT and more importantly FT but also drive up estradiol and in some cases much more than expected depending on how the individual responds to said protocol (dose/injection frequency).
Some men experience a big jump in estradiol which can cause issues for some especially when it comes to libido and erectile function/penile sensitivity.
It is pretty much a given that in most cases use of hCG or better yet hCG + FSH will minimize/prevent testicular atrophy and maintain fertility.
Far from a given that it is going to have a positive impact on your mood, libido and erectile function/sensitivity!
Some feel great when using hCG whereas others may struggle!
Only time will tell through trial and error.
My reply from a previous thread:
If you are just starting TTh then in order to minimize/prevent testicular atrophy 1500 IU once weekly should suffice or better yet 500 IU 2-3X weekly.
The sweet spot would most likely be 250-500 IU 2-3X weekly in order to stimulate maximum ITT (intratesticular testosterone) production which should have a strong impact on minimizing/preventing testicular atrophy and maintaining fertility.
In some cases especially when it comes to fertility the addition of FSH may be needed
If you have been on TTh solo for a long time (years) then you will most likely need much higher doses then 1500 IU once weekly/500 IU twice weekly as your leydig cells will have been dormant for so long and they are more prone to being what we call stubborn to the LH signal.
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