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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
HELP - Doubts about TRT
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<blockquote data-quote="Cataceous" data-source="post: 279143" data-attributes="member: 38109"><p>The problem is they did not measure SHBG or free testosterone. When there are variations in SHBG, which is particularly true of the obese, then total testosterone becomes a less valid measure of testosterone sufficiency. Free testosterone should be used instead.</p><p></p><p></p><p>People of the same weight can have different SHBG levels, but the rest is not correct. The level of SHBG does not affect free testosterone. The myth may stem in part from the belief that the dose of testosterone directly drives total testosterone. If total testosterone were fixed then changes in SHBG would alter free testosterone. But this is not the case. The dose rate or production rate of testosterone directly drives free testosterone. Total testosterone just follows along, and is also a function of SHBG.</p><p></p><p>The results for young vs old men are actually the opposite. Metabolism slows in older men, so they have higher levels of free testosterone at the same dose. Non-obese older men also tend to have higher SHBG, which further inflates total testosterone.</p></blockquote><p></p>
[QUOTE="Cataceous, post: 279143, member: 38109"] The problem is they did not measure SHBG or free testosterone. When there are variations in SHBG, which is particularly true of the obese, then total testosterone becomes a less valid measure of testosterone sufficiency. Free testosterone should be used instead. People of the same weight can have different SHBG levels, but the rest is not correct. The level of SHBG does not affect free testosterone. The myth may stem in part from the belief that the dose of testosterone directly drives total testosterone. If total testosterone were fixed then changes in SHBG would alter free testosterone. But this is not the case. The dose rate or production rate of testosterone directly drives free testosterone. Total testosterone just follows along, and is also a function of SHBG. The results for young vs old men are actually the opposite. Metabolism slows in older men, so they have higher levels of free testosterone at the same dose. Non-obese older men also tend to have higher SHBG, which further inflates total testosterone. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
HELP - Doubts about TRT
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