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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
HELP - Doubts about TRT
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<blockquote data-quote="Cataceous" data-source="post: 279097" data-attributes="member: 38109"><p>We've been discussing this old myth for several years now. Changes in SHBG do not affect free testosterone once steady state is achieved. The production rate or dose rate of testosterone directly and proportionally drive free testosterone. Total testosterone is a dependent variable, basically a function of free testosterone, SHBG and albumin. Think of SHBG as a storage reservoir for testosterone; add more and before long the reservoir fills, increasing total testosterone. Free testosterone is only altered transiently, but must return to its original value that is determined by the rate of testosterone entering the blood.</p><p></p><p></p><p>Surprisingly there's more complexity on the protocol side. Metabolism occurs mainly in the liver at a rate proportional to free testosterone. The constant of proportionality determines the level of free testosterone seen in response to a given production rate. Variations in this constant are what drive differences in dose-response between individuals who are otherwise identical. As this constant is a physiological parameter with connections to liver function there are not going to be extreme variations among individuals in good heath.</p><p></p><p>On the protocol side you have to account for the area under the curve, which is difficult to do if your protocol leads to variations in serum levels. The simplest was around this is to inject a long testosterone ester frequently so that variation is minimal. Otherwise you have to consider the decay characteristics, which depend on things like the ester, IM/SC, injection site, activity level, etc.</p><p></p><p></p><p>In taking 120 mg TC/week you were averaging 12 mg of testosterone a day, which is objectively supra-physiological. This is according to published research, not my opinion. How you feel on the protocol does not alter the fact. Why not just acknowledge it without being defensive? If you accept the risks then no problem. There's little doubt you had high levels of free testosterone on the protocol. Leave it at that and don't try to redefine what is physiological. Doing otherwise harms men new to TRT who are not as tolerant of high levels as you are.</p></blockquote><p></p>
[QUOTE="Cataceous, post: 279097, member: 38109"] We've been discussing this old myth for several years now. Changes in SHBG do not affect free testosterone once steady state is achieved. The production rate or dose rate of testosterone directly and proportionally drive free testosterone. Total testosterone is a dependent variable, basically a function of free testosterone, SHBG and albumin. Think of SHBG as a storage reservoir for testosterone; add more and before long the reservoir fills, increasing total testosterone. Free testosterone is only altered transiently, but must return to its original value that is determined by the rate of testosterone entering the blood. Surprisingly there's more complexity on the protocol side. Metabolism occurs mainly in the liver at a rate proportional to free testosterone. The constant of proportionality determines the level of free testosterone seen in response to a given production rate. Variations in this constant are what drive differences in dose-response between individuals who are otherwise identical. As this constant is a physiological parameter with connections to liver function there are not going to be extreme variations among individuals in good heath. On the protocol side you have to account for the area under the curve, which is difficult to do if your protocol leads to variations in serum levels. The simplest was around this is to inject a long testosterone ester frequently so that variation is minimal. Otherwise you have to consider the decay characteristics, which depend on things like the ester, IM/SC, injection site, activity level, etc. In taking 120 mg TC/week you were averaging 12 mg of testosterone a day, which is objectively supra-physiological. This is according to published research, not my opinion. How you feel on the protocol does not alter the fact. Why not just acknowledge it without being defensive? If you accept the risks then no problem. There's little doubt you had high levels of free testosterone on the protocol. Leave it at that and don't try to redefine what is physiological. Doing otherwise harms men new to TRT who are not as tolerant of high levels as you are. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
HELP - Doubts about TRT
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