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Thyroid, Pregnenolone, Progesterone, DHEA, etc
Thyroid, DHEA, Pregnenolone, Progesterone, etc
Help determining proper pregnenolone dosage and frequency
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<blockquote data-quote="JA Battle" data-source="post: 212785" data-attributes="member: 40068"><p>Larger single doses are also preferentially converted into progesterone, it’s metabolite allopregnenolone and pregnenolone’s sulfated form, pregnenolone sulfate.</p><p></p><p>A human synthesizes between 30-50 mg of pregnenolone daily. So it’s probably the most natural to take 10mg with three meals. Higher test doses probably warrant an increase in pregnenolone. Also if one is on trt with no hcg, it likely reduces how much pregnenolone is converted to progesterone and dhea due to the STAR enzyme that requires LH.</p><p></p><p>I’d say that conversion will be altered more to pregnenolone sulfate in this scenario but that is just a semi educated guess.</p><p></p><p>If one is not on hcg I’d say that taking</p><p></p><p>10mg of oral pregnenolone three times daily, 1mg to 3mg oral progesterone three times daily.</p><p></p><p>If one is on hcg I’d say just take 5mg pregnenolone 3 times daily with no progesterone at first and then consider .5 to 1.5 mg oral progesterone three times daily.</p><p></p><p>This is just a conservative low dose. Per individual, increases of one or both could be warranted.</p><p></p><p>Missing long is the same as missing short. To me, it makes the most sense to miss short and work your way up but these doses I think would benefit many and is a good starting point if one wants to be methodical about upstream hormone replacement.</p><p></p><p>If serum dheas is not at least half range then I’d say oral .5mg three times daily. We only produce 2-5mg of dhea daily. Slowly dheaS stores will increase. We make 25mg of dheaS daily but I don’t think we get there by blasting ourselves with supraphysiological doses of dhea.</p><p></p><p>The next thought is to see what the oral bioavailability of dheaS is and learn more about oral metabolism of dhea. It may be wise to supplement dheaS directly which I have done.</p></blockquote><p></p>
[QUOTE="JA Battle, post: 212785, member: 40068"] Larger single doses are also preferentially converted into progesterone, it’s metabolite allopregnenolone and pregnenolone’s sulfated form, pregnenolone sulfate. A human synthesizes between 30-50 mg of pregnenolone daily. So it’s probably the most natural to take 10mg with three meals. Higher test doses probably warrant an increase in pregnenolone. Also if one is on trt with no hcg, it likely reduces how much pregnenolone is converted to progesterone and dhea due to the STAR enzyme that requires LH. I’d say that conversion will be altered more to pregnenolone sulfate in this scenario but that is just a semi educated guess. If one is not on hcg I’d say that taking 10mg of oral pregnenolone three times daily, 1mg to 3mg oral progesterone three times daily. If one is on hcg I’d say just take 5mg pregnenolone 3 times daily with no progesterone at first and then consider .5 to 1.5 mg oral progesterone three times daily. This is just a conservative low dose. Per individual, increases of one or both could be warranted. Missing long is the same as missing short. To me, it makes the most sense to miss short and work your way up but these doses I think would benefit many and is a good starting point if one wants to be methodical about upstream hormone replacement. If serum dheas is not at least half range then I’d say oral .5mg three times daily. We only produce 2-5mg of dhea daily. Slowly dheaS stores will increase. We make 25mg of dheaS daily but I don’t think we get there by blasting ourselves with supraphysiological doses of dhea. The next thought is to see what the oral bioavailability of dheaS is and learn more about oral metabolism of dhea. It may be wise to supplement dheaS directly which I have done. [/QUOTE]
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Thyroid, Pregnenolone, Progesterone, DHEA, etc
Thyroid, DHEA, Pregnenolone, Progesterone, etc
Help determining proper pregnenolone dosage and frequency
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