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You might first consider less disruptive ways to raise testosterone, such as Natesto or enclomiphene. Regular TRT has a profound effect on various upstream hormones. At a minimum TRT suppresses GnRH, LH and FSH. It may also affect kisspeptin, progesterone, DHEA and pregnenolone. Although many men seem to do ok in spite of these effects, others end up experiencing problems with libido, sexual function, etc.


If you do proceed with TRT then at least consider physiological dosing. As a "skinny guy" you would likely find that 150 mg TC per week is much more than you need to attain healthy normal levels of testosterone. Consider 100 mg or less. Don't get caught up in the "more is better" mentality surrounding testosterone. More is not better. You're looking for the minimum dose that gives you symptom resolution and normal physiological levels.


TRT Hormone Predictor Widget

TRT Hormone Predictor

Predict estradiol, DHT, and free testosterone levels based on total testosterone

⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

ℹ️ Input Parameters

Normal range: 300-1000 ng/dL

Predicted Hormone Levels

Enter your total testosterone value to see predictions

Results will appear here after calculation

Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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