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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
HCG Questions
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<blockquote data-quote="Cataceous" data-source="post: 139099" data-attributes="member: 38109"><p>Some clarifications on this: The estradiol <em>is</em> a result of aromatase—"Leydig cells have a high capacity for aromatization and ... hCG can acutely stimulate aromatization independently of stimulating testosterone synthesis in vitro."[<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC411596/" target="_blank">1</a>] The reason this estradiol production is resistant to AIs is due to the high concentration of intratesticular testosterone relative to serum levels, ~40 times greater.[<a href="https://onlinelibrary.wiley.com/doi/full/10.1002/j.1939-4640.2004.tb03164.x" target="_blank">2</a>] My assumption is that it's not practical to make intratesticular AI concentrations high enough to counteract this.</p></blockquote><p></p>
[QUOTE="Cataceous, post: 139099, member: 38109"] Some clarifications on this: The estradiol [I]is[/I] a result of aromatase—"Leydig cells have a high capacity for aromatization and ... hCG can acutely stimulate aromatization independently of stimulating testosterone synthesis in vitro."[[URL='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC411596/']1[/URL]] The reason this estradiol production is resistant to AIs is due to the high concentration of intratesticular testosterone relative to serum levels, ~40 times greater.[[URL='https://onlinelibrary.wiley.com/doi/full/10.1002/j.1939-4640.2004.tb03164.x']2[/URL]] My assumption is that it's not practical to make intratesticular AI concentrations high enough to counteract this. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
HCG Questions
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