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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
HCG Efficacy: Should We Measure 17-OH-progesterone to Titrate HCG Dose?
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<blockquote data-quote="Dr Justin Saya MD" data-source="post: 54818" data-attributes="member: 12687"><p>Treating both males AND females gives me a much deeper understanding of sex hormones than I would have if I only treated males. </p><p></p><p>Estradiol (or perhaps more importantly estrogen dominance) is well known to cause fluid retention in females during various parts of the menstrual cycle. The same can occur for males with increases in estradiol (especially if progesterone is near undetectable levels). </p><p></p><p>Below is one description of a mechanism.</p><p></p><p><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3984489/#!po=54.6296" target="_blank">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3984489/#!po=54.6296</a></p><p></p><p>"Estradiol stimulates the liver to synthesize angiotensinogen, a substrate to the kidney hormone renin. Renin is necessary to form angiotensin I that is subsequently converted to angiotensin II (ANG II) by angiotensin-converting enzyme. Angiotensin II, one of the most powerful vasoconstrictors in the body, can increase blood pressure and also stimulate the adrenal gland to release aldosterone. Aldosterone is a primary hormone involved in tubular-regulated sodium retention by the kidney, and this greater sodium retention usually results in water retention. In our studies during hypertonic saline infusions in older women, we found that the primary cause of the estrogen-related water retention was a reduction in sodium and total osmol excretion, consistent with other studies in PM women during long-term estrogen therapy."</p></blockquote><p></p>
[QUOTE="Dr Justin Saya MD, post: 54818, member: 12687"] Treating both males AND females gives me a much deeper understanding of sex hormones than I would have if I only treated males. Estradiol (or perhaps more importantly estrogen dominance) is well known to cause fluid retention in females during various parts of the menstrual cycle. The same can occur for males with increases in estradiol (especially if progesterone is near undetectable levels). Below is one description of a mechanism. [url]https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3984489/#!po=54.6296[/url] "Estradiol stimulates the liver to synthesize angiotensinogen, a substrate to the kidney hormone renin. Renin is necessary to form angiotensin I that is subsequently converted to angiotensin II (ANG II) by angiotensin-converting enzyme. Angiotensin II, one of the most powerful vasoconstrictors in the body, can increase blood pressure and also stimulate the adrenal gland to release aldosterone. Aldosterone is a primary hormone involved in tubular-regulated sodium retention by the kidney, and this greater sodium retention usually results in water retention. In our studies during hypertonic saline infusions in older women, we found that the primary cause of the estrogen-related water retention was a reduction in sodium and total osmol excretion, consistent with other studies in PM women during long-term estrogen therapy." [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
HCG Efficacy: Should We Measure 17-OH-progesterone to Titrate HCG Dose?
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