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Thyroid, Pregnenolone, Progesterone, DHEA, etc
Thyroid, DHEA, Pregnenolone, Progesterone, etc
HCG Effects on Thyroid Function
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<blockquote data-quote="tareload" data-source="post: 244317"><p>[URL unfurl="true"]https://etj.bioscientifica.com/view/journals/etj/11/6/ETJ-22-0145.xml[/URL]</p><p></p><p></p><p>We showed that fT4 concentrations measured using both LC-MS/MS and IAs were significantly lower in the samples of pregnant women compared to the samples of healthy controls, which is supported by previous literature (<a href="https://etj.bioscientifica.com/view/journals/etj/11/6/ETJ-22-0145.xml#bib22" target="_blank">22</a>, <a href="https://etj.bioscientifica.com/view/journals/etj/11/6/ETJ-22-0145.xml#bib23" target="_blank">23</a>). In a healthy, iodine-sufficient pregnant population, this is an observation considered normal physiology and not the result of a technical artifact of the measurement method. Although there has been no definite explanation for why serum fT4 concentration is decreased during pregnancy, several mechanisms are suggested to underlie this observation. HCG increases estrogen concentrations during pregnancy and consequently, estrogen increases TBG concentrations causing more T4 to bind to TBG which might lead to short-term lower freely circulating T4 (<a href="https://etj.bioscientifica.com/view/journals/etj/11/6/ETJ-22-0145.xml#bib24" target="_blank">24</a>). On the other hand, albumin concentrations decrease during pregnancy because of a dilution effect caused by an increased total blood volume (<a href="https://etj.bioscientifica.com/view/journals/etj/11/6/ETJ-22-0145.xml#bib25" target="_blank">25</a>). Although the changes in binding protein concentration will alter the total amount of bound T4, the fT4 concentration is dependent upon feedback from the pituitary by thyroid-stimulating hormone (TSH). A short-term inappropriately decreased fT4 will be sensed by the pituitary and lead to an increased TSH and stimulation of the thyroid gland to produce T4 which will ultimately result in an fT4 suitable for normal physiology during pregnancy</p></blockquote><p></p>
[QUOTE="tareload, post: 244317"] [URL unfurl="true"]https://etj.bioscientifica.com/view/journals/etj/11/6/ETJ-22-0145.xml[/URL] We showed that fT4 concentrations measured using both LC-MS/MS and IAs were significantly lower in the samples of pregnant women compared to the samples of healthy controls, which is supported by previous literature ([URL='https://etj.bioscientifica.com/view/journals/etj/11/6/ETJ-22-0145.xml#bib22']22[/URL], [URL='https://etj.bioscientifica.com/view/journals/etj/11/6/ETJ-22-0145.xml#bib23']23[/URL]). In a healthy, iodine-sufficient pregnant population, this is an observation considered normal physiology and not the result of a technical artifact of the measurement method. Although there has been no definite explanation for why serum fT4 concentration is decreased during pregnancy, several mechanisms are suggested to underlie this observation. HCG increases estrogen concentrations during pregnancy and consequently, estrogen increases TBG concentrations causing more T4 to bind to TBG which might lead to short-term lower freely circulating T4 ([URL='https://etj.bioscientifica.com/view/journals/etj/11/6/ETJ-22-0145.xml#bib24']24[/URL]). On the other hand, albumin concentrations decrease during pregnancy because of a dilution effect caused by an increased total blood volume ([URL='https://etj.bioscientifica.com/view/journals/etj/11/6/ETJ-22-0145.xml#bib25']25[/URL]). Although the changes in binding protein concentration will alter the total amount of bound T4, the fT4 concentration is dependent upon feedback from the pituitary by thyroid-stimulating hormone (TSH). A short-term inappropriately decreased fT4 will be sensed by the pituitary and lead to an increased TSH and stimulation of the thyroid gland to produce T4 which will ultimately result in an fT4 suitable for normal physiology during pregnancy [/QUOTE]
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Thyroid, Pregnenolone, Progesterone, DHEA, etc
Thyroid, DHEA, Pregnenolone, Progesterone, etc
HCG Effects on Thyroid Function
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