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HCG and elevated LH in Alzheimer patients
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<blockquote data-quote="Cataceous" data-source="post: 269530" data-attributes="member: 38109"><p>In general sublingual delivery makes me a little uneasy. You get these large spikes in serum levels, which may be undesirable. I did some experimenting with sildenafil, and sublingual proved to be a sure way to induce side effects, whereas oral was ok. Arguably dose titration would help, given the better efficiency of sublingual delivery. There are situations where pulsatile delivery could be advantageous. I'm thinking of hormones that have natural pulsatile delivery, such as testosterone and GnRH. I don't have anything specific to add about selegiline. I wonder if the apparent half-life is reduced with sublingual delivery—and does this matter with a suicide inhibitor?</p><p></p><p>That's a sharp memory to recall my remark on phenethylamine. I do view this as an advantage in taking selegiline orally. It allows good results with even a very low dose of phenethylamine, around 50-100 mg. For me it's become somewhat of a caffeine substitute—minus the side effects.</p></blockquote><p></p>
[QUOTE="Cataceous, post: 269530, member: 38109"] In general sublingual delivery makes me a little uneasy. You get these large spikes in serum levels, which may be undesirable. I did some experimenting with sildenafil, and sublingual proved to be a sure way to induce side effects, whereas oral was ok. Arguably dose titration would help, given the better efficiency of sublingual delivery. There are situations where pulsatile delivery could be advantageous. I'm thinking of hormones that have natural pulsatile delivery, such as testosterone and GnRH. I don't have anything specific to add about selegiline. I wonder if the apparent half-life is reduced with sublingual delivery—and does this matter with a suicide inhibitor? That's a sharp memory to recall my remark on phenethylamine. I do view this as an advantage in taking selegiline orally. It allows good results with even a very low dose of phenethylamine, around 50-100 mg. For me it's become somewhat of a caffeine substitute—minus the side effects. [/QUOTE]
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HCG and elevated LH in Alzheimer patients
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