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Yes and probably. I perceived improvements in cognition that correlated with the use of gonadorelin and enclomiphene. However, one possible confounding factor is that I had started taking selegiline in a similar time frame. I would tend to attribute more of the possible improvements to the GnRH, but for all I know there could be a synergistic effect. I doubt increased LH was much of a factor, as levels barely entered the normal range. Experiments in mice are promising: "A striking observation was that GnRH promoted adult neurogenesis despite aging." "GnRH led to an amelioration of aging-related cognitive decline .... Thus, prolonged elevation of systemic GnRH can cumulatively yield actions on the brain;..." Discussed here.


TRT Hormone Predictor Widget

TRT Hormone Predictor

Predict estradiol, DHT, and free testosterone levels based on total testosterone

⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

ℹ️ Input Parameters

Normal range: 300-1000 ng/dL

Predicted Hormone Levels

Enter your total testosterone value to see predictions

Results will appear here after calculation

Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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