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HCG and elevated LH in Alzheimer patients
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<blockquote data-quote="Cataceous" data-source="post: 225586" data-attributes="member: 38109"><p>Yes, LH does tend to increase in males, presumably from reduced gonadal function:</p><p></p><p style="margin-left: 20px"><em>As men age, there is a small and progressive (not precipitous, as in women) decline in several sex hormones, in particular testosterone and dehydroepiandrosterone, and <strong>related increases in luteinizing hormone, follicle-stimulating hormone</strong>, and sex hormone-binding globulin.</em>[<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3073592/" target="_blank">R</a>]</p><p></p><p>Perhaps, but there are at least suggestions that concomitantly driving GnRH to zero could be bad for the brain.[<a href="https://www.excelmale.com/forum/threads/is-gnrh-suppression-hurting-us.20407/" target="_blank">R</a>]</p><p></p><p>We can make some very crude estimates. If we use <a href="https://www.defymedical.com/blog/quantitative-serum-hcg-case-studies-150iu-and-500iu" target="_blank">Dr. Saya's case study</a> then the area under the curve from a 500 IU injection is about 174 mIU/mL-hours. Injecting twice a week gives you 348 mIU/mL-hours. Dividing by hours in a week gives you an average exposure of 2.1 mIU/mL. You might think this is low, but Marco Filicori <a href="http://comtecmed.com/COGI/COGI9/Uploads/assets/presentations/filicori.pdf" target="_blank">cites</a> a conversion rate of "1 IU hCG = 6-8 IU LH". In reality it's more complicated, with differing relative activities in different tissues. Nonetheless, the implication is that serum hCG of ~2 mIU/mL could be like having supraphysiological LH.</p><p></p><p>These estimates are too shaky for anyone to make significant protocol changes as a result. But if you can get the same results with lower doses then that's a reasonable thing to do.</p></blockquote><p></p>
[QUOTE="Cataceous, post: 225586, member: 38109"] Yes, LH does tend to increase in males, presumably from reduced gonadal function: [INDENT][I]As men age, there is a small and progressive (not precipitous, as in women) decline in several sex hormones, in particular testosterone and dehydroepiandrosterone, and [B]related increases in luteinizing hormone, follicle-stimulating hormone[/B], and sex hormone-binding globulin.[/I][[URL='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3073592/']R[/URL]][/INDENT] Perhaps, but there are at least suggestions that concomitantly driving GnRH to zero could be bad for the brain.[[URL='https://www.excelmale.com/forum/threads/is-gnrh-suppression-hurting-us.20407/']R[/URL]] We can make some very crude estimates. If we use [URL='https://www.defymedical.com/blog/quantitative-serum-hcg-case-studies-150iu-and-500iu']Dr. Saya's case study[/URL] then the area under the curve from a 500 IU injection is about 174 mIU/mL-hours. Injecting twice a week gives you 348 mIU/mL-hours. Dividing by hours in a week gives you an average exposure of 2.1 mIU/mL. You might think this is low, but Marco Filicori [URL='http://comtecmed.com/COGI/COGI9/Uploads/assets/presentations/filicori.pdf']cites[/URL] a conversion rate of "1 IU hCG = 6-8 IU LH". In reality it's more complicated, with differing relative activities in different tissues. Nonetheless, the implication is that serum hCG of ~2 mIU/mL could be like having supraphysiological LH. These estimates are too shaky for anyone to make significant protocol changes as a result. But if you can get the same results with lower doses then that's a reasonable thing to do. [/QUOTE]
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HCG and elevated LH in Alzheimer patients
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