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Yes, LH does tend to increase in males, presumably from reduced gonadal function:


As men age, there is a small and progressive (not precipitous, as in women) decline in several sex hormones, in particular testosterone and dehydroepiandrosterone, and related increases in luteinizing hormone, follicle-stimulating hormone, and sex hormone-binding globulin.[R]


Perhaps, but there are at least suggestions that concomitantly driving GnRH to zero could be bad for the brain.[R]


We can make some very crude estimates. If we use Dr. Saya's case study then the area under the curve from a 500 IU injection is about 174 mIU/mL-hours. Injecting twice a week gives you 348 mIU/mL-hours. Dividing by hours in a week gives you an average exposure of 2.1 mIU/mL. You might think this is low, but Marco Filicori cites a conversion rate of "1 IU hCG = 6-8 IU LH". In reality it's more complicated, with differing relative activities in different tissues. Nonetheless, the implication is that serum hCG of ~2 mIU/mL could be like having supraphysiological LH.


These estimates are too shaky for anyone to make significant protocol changes as a result. But if you can get the same results with lower doses then that's a reasonable thing to do.


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