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HCG and elevated LH in Alzheimer patients
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<blockquote data-quote="Cataceous" data-source="post: 225551" data-attributes="member: 38109"><p>However, the incidence of Alzheimer's disease doesn't correlate with the level of exposure to water, while it does correlate with the levels of gonadotropins. They used to think that reduced estrogen was the problem, but HRT studies have cast doubt on that hypothesis. Even if the link is causal it would be just one risk factor of many and probably not grounds for panic. It seems prudent to use the lowest effective dose of hCG. <s>A concern is that its half-life when injected is orders of magnitude larger than natural LH, which significantly increases the total exposure</s>. It's possible that using hCG makes a man's risk of having AD comparable to a woman's risk.</p><p></p><p>Edit: I think it may be the distribution half-life that differentiates between IM/SC injected hCG/LH and endogenous LH. Endogenous delivery is more directly into the bloodstream, allowing for pulses that are relatively high compared to average serum levels. With SC/IM injections the levels change more slowly, so you cannot emulate the endogenous behavior.</p></blockquote><p></p>
[QUOTE="Cataceous, post: 225551, member: 38109"] However, the incidence of Alzheimer's disease doesn't correlate with the level of exposure to water, while it does correlate with the levels of gonadotropins. They used to think that reduced estrogen was the problem, but HRT studies have cast doubt on that hypothesis. Even if the link is causal it would be just one risk factor of many and probably not grounds for panic. It seems prudent to use the lowest effective dose of hCG. [S]A concern is that its half-life when injected is orders of magnitude larger than natural LH, which significantly increases the total exposure[/S]. It's possible that using hCG makes a man's risk of having AD comparable to a woman's risk. Edit: I think it may be the distribution half-life that differentiates between IM/SC injected hCG/LH and endogenous LH. Endogenous delivery is more directly into the bloodstream, allowing for pulses that are relatively high compared to average serum levels. With SC/IM injections the levels change more slowly, so you cannot emulate the endogenous behavior. [/QUOTE]
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HCG and elevated LH in Alzheimer patients
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