Ditto for me on T3 and LDL reduction as it works directly on those receptors. Was hoping to keep increasing, but it's not a linear equation and there are many other issues that can complicate adjusting the dose. What's a right dose today may not be in 6 months as everything can and does change. I have been struggling with different thyroid combos and meds for the last 10 years and still not there! I think a lot has to do with genetic polymorphisms that reduce the ability of the deiodinase enzymes to convert T4 to T3 and that the rate of such conversion in those affected may vary widely over time, thus causing one to go from optimized to hyper or hypo. Then there's the problem with keeping ferritin/iron levels optimized in order for thyroid hormones to work, then there's cortisol, MTHFR, heavy metals, the list goes on. I envy the people that never seems to have a problem and stay at the same dose forever.
