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Thanks for the update on quantities. Wow. 20% cream in a TopiClick at 400mgx2=800mg/day would get expensive. Through Defy you pay $72 per 30ml TopiClick plus shipping. 50mg per click=16 clicks for 800mg/day. Topiclick has 120 clicks, so 7.5 days. So about $10/day at that rate! Almost bathing in the cream at that point. 100mgx2=200mg/day, about $2.50/day is a lot more reasonable. And you can get more absorption by using a hot/wet compress before application to hydrate.