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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone and Men's Health Articles
Harmonized reference ranges for Total and Free T levels
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<blockquote data-quote="madman" data-source="post: 218735" data-attributes="member: 13851"><p><strong><em>*Nonlinear association and allosteric interactions between hormone binding sites on human serum albumin (HAS) and SHBG allow dynamic regulation of hormone bioavailability</em></strong></p><p><strong><em></em></strong></p><p><strong><em>*SHBG is a dimeric glycoprotein; each monomer of SHBG dimer has a single binding site for testosterone and estradiol</em></strong></p><p><strong><em></em></strong></p><p><strong><em>*HSA has multiple binding sites (<u>at least 6, likely more</u>) for testosterone that also can bind free fatty acids and some commonly used drugs </em></strong></p><p><strong><em></em></strong></p><p><strong><em>*The binding of testosterone to 1 binding site on SHBG and HAS induces allosteric coupling with other binding sites. <u>The allosteric coupling between the multiple sites on binding proteins alters the apparent binding affinity as relative and absolute concentrations change several orders of magnitude during reproductive and nonreproductive phases of a person’s life</u></em></strong></p></blockquote><p></p>
[QUOTE="madman, post: 218735, member: 13851"] [B][I]*Nonlinear association and allosteric interactions between hormone binding sites on human serum albumin (HAS) and SHBG allow dynamic regulation of hormone bioavailability *SHBG is a dimeric glycoprotein; each monomer of SHBG dimer has a single binding site for testosterone and estradiol *HSA has multiple binding sites ([U]at least 6, likely more[/U]) for testosterone that also can bind free fatty acids and some commonly used drugs *The binding of testosterone to 1 binding site on SHBG and HAS induces allosteric coupling with other binding sites. [U]The allosteric coupling between the multiple sites on binding proteins alters the apparent binding affinity as relative and absolute concentrations change several orders of magnitude during reproductive and nonreproductive phases of a person’s life[/U][/I][/B] [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone and Men's Health Articles
Harmonized reference ranges for Total and Free T levels
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