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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone and Men's Health Articles
Harmonized reference ranges for Total and Free T levels
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<blockquote data-quote="madman" data-source="post: 218714" data-attributes="member: 13851"><p><strong>Fig. 1. <u>Dynamic regulation of testosterone bioavailability in the systemic circulation</u>. Circulating testosterone binds with high affinity to SHBG and with a lower affinity weakly to other human serum albumin (HSA), orosomucoid (ORM), and corticosteroid-binding globulin (CBG). The bioavailability of testosterone is influenced by competitive displacement by other biomolecules and altered SHBG levels in many clinical conditions. Free testosterone refers to the fraction of circulating testosterone that is, not bound to any plasma protein and is able to cross the cell membrane. The term, bioavailable testosterone, refers to the fraction of circulating testosterone that is not bound to SHBG; this term reflects the view that testosterone bound to HSA, being bound with low affinity, can dissociate at the capillary level and become bioavailable in some tissues. Testosterone binds to multiple binding sites on HSA that are shared by free fatty acids and many commonly used drugs. In many physiologic and disease conditions, free fatty acids and some commonly used drugs can displace testosterone from these binding sites and influence its bioavailability. (Adapted from Goldman AL, Bhasin S, Wu FCW, Krishna M, Matsumoto AM, Jasuja R. A Reappraisal of Testosterone’s Binding in Circulation: Physiological and Clinical Implications. Endocr Rev. 2017 Aug 1;38(4):302-324.)</strong></p><p><strong>[ATTACH=full]20030[/ATTACH]</strong></p></blockquote><p></p>
[QUOTE="madman, post: 218714, member: 13851"] [B]Fig. 1. [U]Dynamic regulation of testosterone bioavailability in the systemic circulation[/U]. Circulating testosterone binds with high affinity to SHBG and with a lower affinity weakly to other human serum albumin (HSA), orosomucoid (ORM), and corticosteroid-binding globulin (CBG). The bioavailability of testosterone is influenced by competitive displacement by other biomolecules and altered SHBG levels in many clinical conditions. Free testosterone refers to the fraction of circulating testosterone that is, not bound to any plasma protein and is able to cross the cell membrane. The term, bioavailable testosterone, refers to the fraction of circulating testosterone that is not bound to SHBG; this term reflects the view that testosterone bound to HSA, being bound with low affinity, can dissociate at the capillary level and become bioavailable in some tissues. Testosterone binds to multiple binding sites on HSA that are shared by free fatty acids and many commonly used drugs. In many physiologic and disease conditions, free fatty acids and some commonly used drugs can displace testosterone from these binding sites and influence its bioavailability. (Adapted from Goldman AL, Bhasin S, Wu FCW, Krishna M, Matsumoto AM, Jasuja R. A Reappraisal of Testosterone’s Binding in Circulation: Physiological and Clinical Implications. Endocr Rev. 2017 Aug 1;38(4):302-324.) [ATTACH type="full"]20030[/ATTACH][/B] [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone and Men's Health Articles
Harmonized reference ranges for Total and Free T levels
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