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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Half lives of testosterone, hCG, anastrozole and clomiphene.
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<blockquote data-quote="Dr. John Crisler" data-source="post: 98390" data-attributes="member: 91"><p>That's a great report on half-lives!</p><p></p><p>Having said that, the "strategy" of TRT trumps half-life. And the tissue level of the medication, in relation to T concentration, also really counts.</p><p></p><p>As an example, if you are injecting Test cyp once per week, you may just need some anastrozole to help get you over the hump, when T is the highest (and so more conversion to E). And then no more for the rest of the week.</p><p></p><p>or, if you are injecting twice per week (every 3.5 days), you may just take it on shot day each time, for the same reason. IOW, you never reach steady state. in these examples, reaching steady state could leave you too low the rest of the week.</p><p></p><p>The concentration of SHBG changes the entire landscape, as it ranges from low to high. That is because urinary excretion of T increases with higher concentration of T, and/or low(er) SHBG.</p><p></p><p>The only time I think of steady state with AI's is with TD's, or QOD shots.</p><p></p><p>....then there is the fact the shape of the tissue concentration curve also imparts information to the tissues.</p></blockquote><p></p>
[QUOTE="Dr. John Crisler, post: 98390, member: 91"] That's a great report on half-lives! Having said that, the "strategy" of TRT trumps half-life. And the tissue level of the medication, in relation to T concentration, also really counts. As an example, if you are injecting Test cyp once per week, you may just need some anastrozole to help get you over the hump, when T is the highest (and so more conversion to E). And then no more for the rest of the week. or, if you are injecting twice per week (every 3.5 days), you may just take it on shot day each time, for the same reason. IOW, you never reach steady state. in these examples, reaching steady state could leave you too low the rest of the week. The concentration of SHBG changes the entire landscape, as it ranges from low to high. That is because urinary excretion of T increases with higher concentration of T, and/or low(er) SHBG. The only time I think of steady state with AI's is with TD's, or QOD shots. ....then there is the fact the shape of the tissue concentration curve also imparts information to the tissues. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Half lives of testosterone, hCG, anastrozole and clomiphene.
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