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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Half lives of testosterone, hCG, anastrozole and clomiphene.
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<blockquote data-quote="Dr. John Crisler" data-source="post: 97699" data-attributes="member: 91"><p>It's important to know dosing of medications used in Interventional Endocrinology go far beyond a consideration of the half-life of the drug. First, basically, what hormones really do is transmit information around the body. To the cells, where they may interact from the outside of the cell, intracellularly, or even act upon, say, SHBG without even interacting with the cell directly.</p><p></p><p>So the information hormones transmit to cells is not just an off/on matter, nor (competitive) interaction with other hormones in the immediate vicinity of the hormone's receptor. The shape of the curve of hormone concentration is also very important...it's like an analog feature. Rising or lowering--and the rate and acceleration therein--also is very important.</p><p></p><p>This is why, for instance, dosing HCG daily is better than every other day, even though the half-life of HCG is about 2 days. Creating a shorter period saw tooth hormone concentration more closely mimics what you are using the HCG to replace: naturally varying LH level.</p></blockquote><p></p>
[QUOTE="Dr. John Crisler, post: 97699, member: 91"] It's important to know dosing of medications used in Interventional Endocrinology go far beyond a consideration of the half-life of the drug. First, basically, what hormones really do is transmit information around the body. To the cells, where they may interact from the outside of the cell, intracellularly, or even act upon, say, SHBG without even interacting with the cell directly. So the information hormones transmit to cells is not just an off/on matter, nor (competitive) interaction with other hormones in the immediate vicinity of the hormone's receptor. The shape of the curve of hormone concentration is also very important...it's like an analog feature. Rising or lowering--and the rate and acceleration therein--also is very important. This is why, for instance, dosing HCG daily is better than every other day, even though the half-life of HCG is about 2 days. Creating a shorter period saw tooth hormone concentration more closely mimics what you are using the HCG to replace: naturally varying LH level. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Half lives of testosterone, hCG, anastrozole and clomiphene.
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