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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Half lives of testosterone, hCG, anastrozole and clomiphene.
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<blockquote data-quote="DragonBits" data-source="post: 106469" data-attributes="member: 18023"><p>I was thinking about this, and you don't have 2 mg in your system at all times. There is still the "fluctuation" to consider.</p><p></p><p>Once you take <span style="color: #333333"><span style="font-family: 'Arial'">Arimidex on </span></span>10th day, you will have 2 mg in your system AT THAT TIME. During the next 2 days the plasma concentration falls to 1 mg trough. Your next 1 mg dose will raise your plasma concentration to 2 mg.</p><p></p><p></p><p>The reason some people inject testosterone on a shorter schedule than every 8 days is to reduce this fluctuation. Agree, the math will still work out to be the same "stead state" level, but the fluctuation will be reduced.</p><p></p><p></p><p>Also, with testosterone, there is our natural production of testosterone. Without something like HCG, this will gradually fall, I don't think anyone know how fast it falls and I have never seen if natural production actually falls to zero with TRT. With HCG, then who knows what that adds to total testosterone. </p><p></p><p></p><p>So plasma levels of something like testosterone will be very difficult to predict because there are several moving parts. Which is why some people say it takes a while to get "dial in".</p><p></p><p></p><p>There is also "loading dose" where you take more of a drug for the first dose, or you shorten the time between the first and second doses to more quickly reach "steady state". A "loading dose" is more important for a drug that has a longer half life, drugs with a short half life will quickly reach steady state.</p><p></p><p>Correct me if I am wrong about this, but fluctuation seems like an important aspect to understanding half life and steady state.</p></blockquote><p></p>
[QUOTE="DragonBits, post: 106469, member: 18023"] I was thinking about this, and you don't have 2 mg in your system at all times. There is still the "fluctuation" to consider. Once you take [COLOR=#333333][FONT=arial]Arimidex on [/FONT][/COLOR]10th day, you will have 2 mg in your system AT THAT TIME. During the next 2 days the plasma concentration falls to 1 mg trough. Your next 1 mg dose will raise your plasma concentration to 2 mg. The reason some people inject testosterone on a shorter schedule than every 8 days is to reduce this fluctuation. Agree, the math will still work out to be the same "stead state" level, but the fluctuation will be reduced. Also, with testosterone, there is our natural production of testosterone. Without something like HCG, this will gradually fall, I don't think anyone know how fast it falls and I have never seen if natural production actually falls to zero with TRT. With HCG, then who knows what that adds to total testosterone. So plasma levels of something like testosterone will be very difficult to predict because there are several moving parts. Which is why some people say it takes a while to get "dial in". There is also "loading dose" where you take more of a drug for the first dose, or you shorten the time between the first and second doses to more quickly reach "steady state". A "loading dose" is more important for a drug that has a longer half life, drugs with a short half life will quickly reach steady state. Correct me if I am wrong about this, but fluctuation seems like an important aspect to understanding half life and steady state. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Half lives of testosterone, hCG, anastrozole and clomiphene.
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