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Testosterone Replacement, Low T, HCG, & Beyond
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Hair loss
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<blockquote data-quote="ajax31" data-source="post: 181100" data-attributes="member: 39208"><p>[URL unfurl="true"]https://pubmed.ncbi.nlm.nih.gov/21034532/[/URL]</p><p></p><p><span style="font-size: 26px"><strong>Preventable Effect of L-threonate, an Ascorbate Metabolite, on Androgen-Driven Balding via Repression of Dihydrotestosterone-Induced dickkopf-1 Expression in Human Hair Dermal Papilla Cells</strong></span></p><p></p><p><a href="https://pubmed.ncbi.nlm.nih.gov/?term=Kwack+MH&cauthor_id=21034532" target="_blank">Mi Hee Kwack</a> <a href="https://pubmed.ncbi.nlm.nih.gov/21034532/#affiliation-1" target="_blank">1</a>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=Ahn+JS&cauthor_id=21034532" target="_blank">Ji Sup Ahn</a>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=Kim+MK&cauthor_id=21034532" target="_blank">Moon Kyu Kim</a>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=Kim+JC&cauthor_id=21034532" target="_blank">Jung Chul Kim</a>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=Sung+YK&cauthor_id=21034532" target="_blank">Young Kwan Sung</a></p><p></p><ul> <li data-xf-list-type="ul">PMID: <strong>21034532</strong></li> <li data-xf-list-type="ul">DOI: <a href="https://doi.org/10.5483/bmbrep.2010.43.10.688" target="_blank">10.5483/BMBRep.2010.43.10.688</a></li> </ul><p><span style="font-size: 22px"><strong>Abstract</strong></span></p><p>In a previous study, we recently claimed that dihydrotestosterone (DHT)-inducible dickkopf-1 (DKK-1) expression is one of the key factors involved in androgen-potentiated balding. We also demonstrated that L-ascorbic acid 2-phosphate (Asc 2-P) represses DHT-induced DKK-1 expression in cultured dermal papilla cells (DPCs). Here, we investigated whether or not L-threonate could attenuate DHT-induced DKK-1 expression. We observed via RT-PCR analysis and enzyme-linked immunosorbent assay that DHT-induced DKK-1 expression was attenuated in the presence of L-threonate. We also found that DHT-induced activation of DKK-1 promoter activity was significantly repressed by L-threonate. Moreover, a co-culture system featuring outer root sheath (ORS) keratinocytes and DPCs showed that DHT inhibited the growth of ORS cells, which was then significantly reversed by L-threonate. Collectively, these results indicate that L-threonate inhibited DKK-1 expression in DPCs and therefore is a good treatment for the prevention of androgen-driven balding.</p></blockquote><p></p>
[QUOTE="ajax31, post: 181100, member: 39208"] [URL unfurl="true"]https://pubmed.ncbi.nlm.nih.gov/21034532/[/URL] [SIZE=26px][B]Preventable Effect of L-threonate, an Ascorbate Metabolite, on Androgen-Driven Balding via Repression of Dihydrotestosterone-Induced dickkopf-1 Expression in Human Hair Dermal Papilla Cells[/B][/SIZE] [URL='https://pubmed.ncbi.nlm.nih.gov/?term=Kwack+MH&cauthor_id=21034532']Mi Hee Kwack[/URL] [URL='https://pubmed.ncbi.nlm.nih.gov/21034532/#affiliation-1']1[/URL], [URL='https://pubmed.ncbi.nlm.nih.gov/?term=Ahn+JS&cauthor_id=21034532']Ji Sup Ahn[/URL], [URL='https://pubmed.ncbi.nlm.nih.gov/?term=Kim+MK&cauthor_id=21034532']Moon Kyu Kim[/URL], [URL='https://pubmed.ncbi.nlm.nih.gov/?term=Kim+JC&cauthor_id=21034532']Jung Chul Kim[/URL], [URL='https://pubmed.ncbi.nlm.nih.gov/?term=Sung+YK&cauthor_id=21034532']Young Kwan Sung[/URL] [LIST] [*]PMID: [B]21034532[/B] [*]DOI: [URL='https://doi.org/10.5483/bmbrep.2010.43.10.688']10.5483/BMBRep.2010.43.10.688[/URL] [/LIST] [SIZE=22px][B]Abstract[/B][/SIZE] In a previous study, we recently claimed that dihydrotestosterone (DHT)-inducible dickkopf-1 (DKK-1) expression is one of the key factors involved in androgen-potentiated balding. We also demonstrated that L-ascorbic acid 2-phosphate (Asc 2-P) represses DHT-induced DKK-1 expression in cultured dermal papilla cells (DPCs). Here, we investigated whether or not L-threonate could attenuate DHT-induced DKK-1 expression. We observed via RT-PCR analysis and enzyme-linked immunosorbent assay that DHT-induced DKK-1 expression was attenuated in the presence of L-threonate. We also found that DHT-induced activation of DKK-1 promoter activity was significantly repressed by L-threonate. Moreover, a co-culture system featuring outer root sheath (ORS) keratinocytes and DPCs showed that DHT inhibited the growth of ORS cells, which was then significantly reversed by L-threonate. Collectively, these results indicate that L-threonate inhibited DKK-1 expression in DPCs and therefore is a good treatment for the prevention of androgen-driven balding. [/QUOTE]
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