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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
Hair loss
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<blockquote data-quote="Cataceous" data-source="post: 168703" data-attributes="member: 38109"><p>It's hard to dispute a causal link between DHT and hair loss. Stated well <a href="https://perfecthairhealth.com/scalp-tension-hair-loss/" target="_blank">here</a>:</p><p></p><p><em>Firstly, studies show that DHT <a href="http://www.ncbi.nlm.nih.gov/pubmed/4823922" target="_blank">is higher in the scalps of men with thinning hair.</a> Secondly, if a man is castrated, <a href="http://www.ncbi.nlm.nih.gov/pubmed/23769268" target="_blank">his testosterone (and DHT) levels plummet permanently</a>. Men castrated before puberty (i.e., before their DHT levels spike) <a href="http://press.endocrine.org/doi/abs/10.1210/jcem-20-10-1309" target="_blank">don’t go bald later in life</a>. And thirdly, men with a genetic deficiency in an enzyme that converts testosterone into DHT in scalp tissues <a href="https://www.ncbi.nlm.nih.gov/pubmed/4413434" target="_blank">never develop pattern hair loss</a>.</em></p><p><em></em></p><p><em>These are pretty indicting findings. Just look at the endpoints: men who never produce DHT never develop pattern hair loss. Men with higher amounts of DHT in their scalps have AGA. Based on these findings, DHT must play some causal role in AGA.</em></p><p></p><p>But the same article discusses how the DHT link might still be compatible with the scalp-tension hypothesis:</p><p></p><p><em>Question: If DHT causes pattern hair loss, how come eliminating DHT only stops AGA? How come it doesn’t lead to a full hair recovery?</em></p><p><em>...</em></p><p><em>Many researchers have hypothesized that this may be due to DHT’s relationship with scar tissue. In scalp tissues, the arrival of <a href="https://www.ncbi.nlm.nih.gov/pubmed/16755026" target="_blank">DHT seems to also remodel our scalps</a> – causing increased disorganized collagen crosshatchings. In other words, scalp DHT causes fibrosis (or scarring).</em></p><p></p><p><em>In fact, balding scalp regions have <a href="https://link.springer.com/article/10.1007/s00403-007-0826-x" target="_blank">four times the amount of excess collagen deposition</a> (scar tissue) than non-balding regions. And as we’ve learned in scleroderma studies, <a href="https://www.nature.com/articles/sj.bdj.2010.252" target="_blank">where there’s scar tissue, hair cannot grow.</a></em></p></blockquote><p></p>
[QUOTE="Cataceous, post: 168703, member: 38109"] It's hard to dispute a causal link between DHT and hair loss. Stated well [URL='https://perfecthairhealth.com/scalp-tension-hair-loss/']here[/URL]: [I]Firstly, studies show that DHT [URL='http://www.ncbi.nlm.nih.gov/pubmed/4823922']is higher in the scalps of men with thinning hair.[/URL] Secondly, if a man is castrated, [URL='http://www.ncbi.nlm.nih.gov/pubmed/23769268']his testosterone (and DHT) levels plummet permanently[/URL]. Men castrated before puberty (i.e., before their DHT levels spike) [URL='http://press.endocrine.org/doi/abs/10.1210/jcem-20-10-1309']don’t go bald later in life[/URL]. And thirdly, men with a genetic deficiency in an enzyme that converts testosterone into DHT in scalp tissues [URL='https://www.ncbi.nlm.nih.gov/pubmed/4413434']never develop pattern hair loss[/URL]. These are pretty indicting findings. Just look at the endpoints: men who never produce DHT never develop pattern hair loss. Men with higher amounts of DHT in their scalps have AGA. Based on these findings, DHT must play some causal role in AGA.[/I] But the same article discusses how the DHT link might still be compatible with the scalp-tension hypothesis: [I]Question: If DHT causes pattern hair loss, how come eliminating DHT only stops AGA? How come it doesn’t lead to a full hair recovery? ... Many researchers have hypothesized that this may be due to DHT’s relationship with scar tissue. In scalp tissues, the arrival of [URL='https://www.ncbi.nlm.nih.gov/pubmed/16755026']DHT seems to also remodel our scalps[/URL] – causing increased disorganized collagen crosshatchings. In other words, scalp DHT causes fibrosis (or scarring).[/I] [I]In fact, balding scalp regions have [URL='https://link.springer.com/article/10.1007/s00403-007-0826-x']four times the amount of excess collagen deposition[/URL] (scar tissue) than non-balding regions. And as we’ve learned in scleroderma studies, [URL='https://www.nature.com/articles/sj.bdj.2010.252']where there’s scar tissue, hair cannot grow.[/URL][/I] [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
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