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H. Pylori Linked to Atherosclerosis in Healthy People
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<blockquote data-quote="CoastWatcher" data-source="post: 102518" data-attributes="member: 2624"><p><strong><em>Current infection with Helicobacter pylori (H. Pylori) was associated with significant subclinical coronary artery stenosis in a population with no prior arterial disease, suggesting a need for earlier diagnosis and treatment of this pathogen to forestall progression to overt disease, researchers reported.</em></strong></p><p></p><p>"This result suggests the possibility that <em>H. pylori</em> eradication might be worthwhile in preventing coronary artery disease, Shinae Kang, MD, PhD<a href="http://mrss.yonsei.ac.kr/researcher_network/researcher/researcher_profile.asp?rd_no=167" target="_blank">,</a> of Yonsei University College of Medicine in Seoul, South Korea, and colleagues wrote online in <a href="http://journals.plos.org/plosone/article/related?id=10.1371/journal.pone.0193646" target="_blank"><em>PLoS One</em></a>.</p><p></p><p></p><ul> <li data-xf-list-type="ul">To address <em>H. pylori</em>'s impact on the arteries of healthy individuals, Kang's group studied 463 consecutive patients who underwent voluntary health check-ups at Gangnam Severance Hospital in Seoul during 2007-2014. The mean age of participants was 54.2, and 336 were men.</li> <li data-xf-list-type="ul">The patients underwent post-biopsy rapid urease testing of gastric mucosa, using the <em>Campylobacter</em>-like organism test (CLO) and were then divided into two groups based on CLO status. Patients also underwent pulse-wave velocity (PWV) measurement and cardiac multidetector computed tomography.</li> <li data-xf-list-type="ul">With significant coronary artery narrowing defined in the study as &#8805;50% stenosis in any major epicardial coronary vessels or branches, the CLO-positive group (n=224) was more than twice as likely as the CLO-negative group (n=239) to have significant stenosis, with an incidence of 7.6% versus 2.9% (<em>P</em>=0.01).</li> <li data-xf-list-type="ul">Even after the researchers adjusted for confounding factors, the positive group had an adjusted odds ratio of 2.813 (95% CI 1.051-7.528, <em>P</em>=0.04).</li> <li data-xf-list-type="ul">CLO-positive participants also had lower mean high-density lipoprotein cholesterol (HDL) compared with CLO-negative subjects: 46.6 versus 49.6 mg/dL. Triglyceride levels were also higher, at 134.5 versus 116.4 mg/dL. Furthermore, the number of participants who had coronary artery calcium scores >0 was significantly greater in the CLO-positive group, and the number of vessel segments with plaque was slightly higher in CLO-positive patients, at 0.22 versus 0.17 (<em>P</em>=0.03).</li> </ul><p></p><p>"H. Pylori Linked to Atherosclerosis in Healthy People," <em>Medpage Today, </em>March 31, 2018, <a href="https://www.medpagetoday.com/gastroenterology/generalgastroenterology/72089" target="_blank">https://www.medpagetoday.com/gastroenterology/generalgastroenterology/72089</a></p></blockquote><p></p>
[QUOTE="CoastWatcher, post: 102518, member: 2624"] [B][I]Current infection with Helicobacter pylori (H. Pylori) was associated with significant subclinical coronary artery stenosis in a population with no prior arterial disease, suggesting a need for earlier diagnosis and treatment of this pathogen to forestall progression to overt disease, researchers reported.[/I][/B] "This result suggests the possibility that [I]H. pylori[/I] eradication might be worthwhile in preventing coronary artery disease, Shinae Kang, MD, PhD[URL="http://mrss.yonsei.ac.kr/researcher_network/researcher/researcher_profile.asp?rd_no=167"],[/URL] of Yonsei University College of Medicine in Seoul, South Korea, and colleagues wrote online in [URL="http://journals.plos.org/plosone/article/related?id=10.1371/journal.pone.0193646"][I]PLoS One[/I][/URL]. [LIST] [*]To address [I]H. pylori[/I]'s impact on the arteries of healthy individuals, Kang's group studied 463 consecutive patients who underwent voluntary health check-ups at Gangnam Severance Hospital in Seoul during 2007-2014. The mean age of participants was 54.2, and 336 were men. [*]The patients underwent post-biopsy rapid urease testing of gastric mucosa, using the [I]Campylobacter[/I]-like organism test (CLO) and were then divided into two groups based on CLO status. Patients also underwent pulse-wave velocity (PWV) measurement and cardiac multidetector computed tomography. [*]With significant coronary artery narrowing defined in the study as ≥50% stenosis in any major epicardial coronary vessels or branches, the CLO-positive group (n=224) was more than twice as likely as the CLO-negative group (n=239) to have significant stenosis, with an incidence of 7.6% versus 2.9% ([I]P[/I]=0.01). [*]Even after the researchers adjusted for confounding factors, the positive group had an adjusted odds ratio of 2.813 (95% CI 1.051-7.528, [I]P[/I]=0.04). [*]CLO-positive participants also had lower mean high-density lipoprotein cholesterol (HDL) compared with CLO-negative subjects: 46.6 versus 49.6 mg/dL. Triglyceride levels were also higher, at 134.5 versus 116.4 mg/dL. Furthermore, the number of participants who had coronary artery calcium scores >0 was significantly greater in the CLO-positive group, and the number of vessel segments with plaque was slightly higher in CLO-positive patients, at 0.22 versus 0.17 ([I]P[/I]=0.03). [/LIST] "H. Pylori Linked to Atherosclerosis in Healthy People," [I]Medpage Today, [/I]March 31, 2018, [URL]https://www.medpagetoday.com/gastroenterology/generalgastroenterology/72089[/URL] [/QUOTE]
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H. Pylori Linked to Atherosclerosis in Healthy People
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