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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
Gynecomastia: Causes, Types, and Treatments.
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<blockquote data-quote="BigTex" data-source="post: 276028" data-attributes="member: 43589"><p>With E2 and IGF-1, I have to go back to bodybuilding in that many bodybuilders now try to push their E2 levels upward and find a sweet spot. Here is the reason why:</p><p></p><p>Estradiol (E2) can influence the production and release of growth hormone (GH) and insulin-like growth factor 1 (IGF-1) through various mechanisms.</p><ol> <li data-xf-list-type="ol"><strong>Direct Effects on GH Secretion</strong>: Estradiol can directly influence the secretion of GH from the pituitary gland. Studies have shown that estradiol can stimulate the secretion of GH in both animals and humans.</li> <li data-xf-list-type="ol"><strong>Modulation of GH-Releasing Hormone (GHRH) and Somatostatin</strong>: Estradiol can also influence the secretion of GH indirectly by modulating the production and release of GH-releasing hormone (GHRH) and somatostatin, which are hormones that regulate GH secretion. Estradiol can inhibit the release of somatostatin, which normally suppresses GH secretion, leading to an increase in GH release.</li> <li data-xf-list-type="ol"><strong>Regulation of GH Receptor Expression</strong>: Estradiol can also affect the expression of GH receptors in various tissues. GH exerts its effects through binding to GH receptors, and estradiol can modulate the expression of these receptors, thereby influencing the responsiveness of tissues to GH.</li> <li data-xf-list-type="ol"><strong>Indirect Effects on IGF-1</strong>: GH stimulates the production of insulin-like growth factor 1 (IGF-1) in the liver and other tissues. Estradiol can indirectly influence the levels of IGF-1 by modulating GH secretion and GH receptor expression. Higher levels of estradiol may lead to increased GH secretion and enhanced GH receptor expression, resulting in higher levels of IGF-1.</li> </ol></blockquote><p></p>
[QUOTE="BigTex, post: 276028, member: 43589"] With E2 and IGF-1, I have to go back to bodybuilding in that many bodybuilders now try to push their E2 levels upward and find a sweet spot. Here is the reason why: Estradiol (E2) can influence the production and release of growth hormone (GH) and insulin-like growth factor 1 (IGF-1) through various mechanisms. [LIST=1] [*][B]Direct Effects on GH Secretion[/B]: Estradiol can directly influence the secretion of GH from the pituitary gland. Studies have shown that estradiol can stimulate the secretion of GH in both animals and humans. [*][B]Modulation of GH-Releasing Hormone (GHRH) and Somatostatin[/B]: Estradiol can also influence the secretion of GH indirectly by modulating the production and release of GH-releasing hormone (GHRH) and somatostatin, which are hormones that regulate GH secretion. Estradiol can inhibit the release of somatostatin, which normally suppresses GH secretion, leading to an increase in GH release. [*][B]Regulation of GH Receptor Expression[/B]: Estradiol can also affect the expression of GH receptors in various tissues. GH exerts its effects through binding to GH receptors, and estradiol can modulate the expression of these receptors, thereby influencing the responsiveness of tissues to GH. [*][B]Indirect Effects on IGF-1[/B]: GH stimulates the production of insulin-like growth factor 1 (IGF-1) in the liver and other tissues. Estradiol can indirectly influence the levels of IGF-1 by modulating GH secretion and GH receptor expression. Higher levels of estradiol may lead to increased GH secretion and enhanced GH receptor expression, resulting in higher levels of IGF-1. [/LIST] [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
Gynecomastia: Causes, Types, and Treatments.
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