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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
Gynecomastia Associated with a Combination of High IGF-1 and Estradiol In Adolescents
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<blockquote data-quote="Nelson Vergel" data-source="post: 24980" data-attributes="member: 3"><p><strong>A Longitudinal Study of Growth, Sex Steroids and Insulin-like Growth Factor I in boys with Physiological Gynecomastia</strong></p><p></p><p></p><p>Physiological gynecomastia is common in pubertal boys and appears to be associated with increased levels of insulin like growth factor-1 (IGF-1) and pubertal growth, but not with a shift in the balance between estrogen and testosterone, a new study suggests.</p><p></p><p>The findings were <a href="http://press.endocrine.org/doi/abs/10.1210/jc.2015-2836" target="_blank">published online</a> August 19 in the <em>Journal of Clinical Endocrinology and Metabolism</em> by Mikkel G Mieritz, MD, a PhD student working in the department of growth and reproduction, Rigshospitalet, University of Copenhagen, Denmark, and colleagues.</p><p></p><p>In their discussion, Mieritz and colleagues note that IGF-1 together with estrogen is essential for the growth of breast tissue, and it appears that the effect of growth hormone on breast growth is mediated through IGF-1. "The stimulatory effect of IGF-1 on breast formation was synergized by [estradiol], which was also elevated in boys with gynecomastia in our study. However, serum testosterone was similarly elevated, leaving the estradiol/testosterone ratio unaltered."</p><p></p><p><a href="http://press.endocrine.org/doi/10.1210/jc.2015-2836" target="_blank">http://press.endocrine.org/doi/10.1210/jc.2015-2836</a></p></blockquote><p></p>
[QUOTE="Nelson Vergel, post: 24980, member: 3"] [B]A Longitudinal Study of Growth, Sex Steroids and Insulin-like Growth Factor I in boys with Physiological Gynecomastia[/B] Physiological gynecomastia is common in pubertal boys and appears to be associated with increased levels of insulin like growth factor-1 (IGF-1) and pubertal growth, but not with a shift in the balance between estrogen and testosterone, a new study suggests. The findings were [URL='http://press.endocrine.org/doi/abs/10.1210/jc.2015-2836']published online[/URL] August 19 in the [I]Journal of Clinical Endocrinology and Metabolism[/I] by Mikkel G Mieritz, MD, a PhD student working in the department of growth and reproduction, Rigshospitalet, University of Copenhagen, Denmark, and colleagues. In their discussion, Mieritz and colleagues note that IGF-1 together with estrogen is essential for the growth of breast tissue, and it appears that the effect of growth hormone on breast growth is mediated through IGF-1. "The stimulatory effect of IGF-1 on breast formation was synergized by [estradiol], which was also elevated in boys with gynecomastia in our study. However, serum testosterone was similarly elevated, leaving the estradiol/testosterone ratio unaltered." [URL]http://press.endocrine.org/doi/10.1210/jc.2015-2836[/URL] [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
Gynecomastia Associated with a Combination of High IGF-1 and Estradiol In Adolescents
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