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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
Guidelines of care for the management of acne vulgaris
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<blockquote data-quote="madman" data-source="post: 274943" data-attributes="member: 13851"><p><strong>Background</strong></p><p></p><p><em>Acne vulgaris commonly affects adults, adolescents, and preadolescents aged 9 years or older.</em></p><p></p><p></p><p><strong>Objective</strong></p><p></p><p><em>The objective of this study was to provide evidence-based recommendations for themanagement of acne.</em></p><p></p><p></p><p><strong>Methods</strong></p><p></p><p><em>A working group conducted a systematic review and applied the Grading of Recommendations, Assessment, Development, and Evaluation approach for assessing the certainty of evidence and formulating and grading recommendations.</em></p><p></p><p></p><p><strong>Results</strong></p><p></p><p><em>This guideline presents 18 evidence-based recommendations and 5 good practice statements. Strong recommendations are made for benzoyl peroxide, topical retinoids, topical antibiotics, and oral doxycycline. Oral isotretinoin is strongly recommended for acne that is severe, causing psychosocial burden or scarring, or failing standard oral or topical therapy. Conditional recommendations are made for topical clascoterone, salicylic acid, and azelaic acid, as well as for oral minocycline, sarecycline, combined oral contraceptive pills, and spironolactone. Combining topical therapies with multiple mechanisms of action, limiting systemic antibiotic use, combining systemic antibiotics with topical therapies, and adding intralesional corticosteroid injections for larger acne lesions are recommended as good practice statements.</em></p><p></p><p></p><p><strong>Limitations</strong></p><p></p><p><em>Analysis is based on the best available evidence at the time of the systematic review.</em></p><p></p><p></p><p><strong>Conclusions</strong></p><p></p><p><em>These guidelines provide evidence-based recommendations for the management of acne vulgaris. ( J Am Acad Dermatol <a href="https://doi.org/10.1016/j.jaad.2023.12.017" target="_blank">Redirecting</a>.)</em></p><p></p><p></p><p></p><p></p><p><strong>ACNE GRADING AND CLASSIFICATION</strong></p><p><strong></strong></p><p><strong></strong></p><p><strong>MICROBIOLOGICAL AND ENDOCRINE TESTING</strong></p><p><strong></strong></p><p><strong></strong></p><p><strong>ACNE MANAGEMENT</strong></p><p><strong></strong></p><p><strong></strong></p><p><strong>TOPICAL THERAPIES</strong></p><p><em>Topical retinoids</em></p><p><em>Benzoyl peroxide</em></p><p><em>Topical antibiotics</em></p><p><em>Fixed-dose topical combinations</em></p><p><em>Clascoterone</em></p><p><em>Salicylic acid</em></p><p><em>Azelaic acid</em></p><p><em>Considerations in Topical Therapies</em></p><p></p><p></p><p><strong>SYSTEMIC ANTIBIOTICS</strong></p><p><em>Doxycycline</em></p><p><em>Minocycline</em></p><p><em>Sarecycline</em></p><p><em>Considerations in Systemic Antibiotics</em></p><p></p><p></p><p><strong>HORMONAL AGENTS</strong></p><p><em>Combined oral contraceptives</em></p><p><em>Spironolactone</em></p><p><em>Intralesional corticosteroid</em></p><p><em>Considerations in hormonal agents</em></p><p></p><p></p><p><strong>ISOTRETINOIN</strong></p><p><strong></strong></p><p><strong></strong></p><p><strong>PHYSICAL MODALITIES</strong></p><p><strong></strong></p><p><strong></strong></p><p><strong>COMPLEMENTARY/ALTERNATIVE THERAPIES</strong></p><p><strong></strong></p><p><strong></strong></p><p><strong>DIET</strong></p><p><strong></strong></p><p><strong></strong></p><p><strong>GAPS IN RESEARCH AND STUDY LIMITATIONS</strong></p><p><strong></strong></p><p><strong></strong></p><p><strong></strong></p><p><strong></strong></p><p><strong>SUMMARY</strong></p><p><strong></strong></p><p><strong><em>Analysis of the evidence from this systematic review based on 9 clinical questions resulted in 18 evidence-based recommendations and 5 good practice statements for the treatment of acne. Strong recommendations are made for benzoyl peroxide, topical retinoids, and topical antibiotics, as well as for oral doxycycline. Oral isotretinoin is strongly recommended for acne that is severe, causing psychosocial burden or scarring, or failing standard oral or topical therapy. Conditional recommendations are made for topical clascoterone, salicylic acid, azelaic acid, as well as for oral minocycline,sarecycline, COC pills, and spironolactone. Combining topical therapies with multiple mechanisms of action, limiting systemic antibiotic use, combining systemic antibiotics with topical therapies, and adding intralesional corticosteroid injections for larger acne lesions are recommended as good practice statements (Table III).</em></strong></p></blockquote><p></p>
[QUOTE="madman, post: 274943, member: 13851"] [B]Background[/B] [I]Acne vulgaris commonly affects adults, adolescents, and preadolescents aged 9 years or older.[/I] [B]Objective[/B] [I]The objective of this study was to provide evidence-based recommendations for themanagement of acne.[/I] [B]Methods[/B] [I]A working group conducted a systematic review and applied the Grading of Recommendations, Assessment, Development, and Evaluation approach for assessing the certainty of evidence and formulating and grading recommendations.[/I] [B]Results[/B] [I]This guideline presents 18 evidence-based recommendations and 5 good practice statements. Strong recommendations are made for benzoyl peroxide, topical retinoids, topical antibiotics, and oral doxycycline. Oral isotretinoin is strongly recommended for acne that is severe, causing psychosocial burden or scarring, or failing standard oral or topical therapy. Conditional recommendations are made for topical clascoterone, salicylic acid, and azelaic acid, as well as for oral minocycline, sarecycline, combined oral contraceptive pills, and spironolactone. Combining topical therapies with multiple mechanisms of action, limiting systemic antibiotic use, combining systemic antibiotics with topical therapies, and adding intralesional corticosteroid injections for larger acne lesions are recommended as good practice statements.[/I] [B]Limitations[/B] [I]Analysis is based on the best available evidence at the time of the systematic review.[/I] [B]Conclusions[/B] [I]These guidelines provide evidence-based recommendations for the management of acne vulgaris. ( J Am Acad Dermatol [URL='https://doi.org/10.1016/j.jaad.2023.12.017']Redirecting[/URL].)[/I] [B]ACNE GRADING AND CLASSIFICATION MICROBIOLOGICAL AND ENDOCRINE TESTING ACNE MANAGEMENT TOPICAL THERAPIES[/B] [I]Topical retinoids Benzoyl peroxide Topical antibiotics Fixed-dose topical combinations Clascoterone Salicylic acid Azelaic acid Considerations in Topical Therapies[/I] [B]SYSTEMIC ANTIBIOTICS[/B] [I]Doxycycline Minocycline Sarecycline Considerations in Systemic Antibiotics[/I] [B]HORMONAL AGENTS[/B] [I]Combined oral contraceptives Spironolactone Intralesional corticosteroid Considerations in hormonal agents[/I] [B]ISOTRETINOIN PHYSICAL MODALITIES COMPLEMENTARY/ALTERNATIVE THERAPIES DIET GAPS IN RESEARCH AND STUDY LIMITATIONS SUMMARY [I]Analysis of the evidence from this systematic review based on 9 clinical questions resulted in 18 evidence-based recommendations and 5 good practice statements for the treatment of acne. Strong recommendations are made for benzoyl peroxide, topical retinoids, and topical antibiotics, as well as for oral doxycycline. Oral isotretinoin is strongly recommended for acne that is severe, causing psychosocial burden or scarring, or failing standard oral or topical therapy. Conditional recommendations are made for topical clascoterone, salicylic acid, azelaic acid, as well as for oral minocycline,sarecycline, COC pills, and spironolactone. Combining topical therapies with multiple mechanisms of action, limiting systemic antibiotic use, combining systemic antibiotics with topical therapies, and adding intralesional corticosteroid injections for larger acne lesions are recommended as good practice statements (Table III).[/I][/B] [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
Guidelines of care for the management of acne vulgaris
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