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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
Gonadorelin alternative to hCG - Kisspeptin a peptide that is not approved for compounding
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<blockquote data-quote="Cataceous" data-source="post: 195170" data-attributes="member: 38109"><p>It's true that if you have a way to constantly infuse GnRH then it does in time shut everything down; the pituitary becomes insensitive to it. In fact this is how most of the GnRH analogs work—intentionally: they have much longer half-lives than GnRH, which results in overexposure of the pituitary.</p><p></p><p>As [USER=40068]@JA Battle[/USER] says, normal HPTA operation requires frequent GnRH pulses. I did encounter some research showing that if there is a longer delay between pulses, e.g. one day, then the corresponding LH pulse is considerably larger. I don't believe this research was designed to see if single daily pulses would work indefinitely. The Royal trials are perhaps suggesting they do.</p><p></p><p></p><p>I'd like to see some hard data on this. Basically he's imputing a very long half-life to whatever abstract process he's sketching on his timeline. I'd like to know if testicular volume would actually have this pattern—that is, be above the "active" line even with infrequent pulses. What about endogenous testosterone production?</p></blockquote><p></p>
[QUOTE="Cataceous, post: 195170, member: 38109"] It's true that if you have a way to constantly infuse GnRH then it does in time shut everything down; the pituitary becomes insensitive to it. In fact this is how most of the GnRH analogs work—intentionally: they have much longer half-lives than GnRH, which results in overexposure of the pituitary. As [USER=40068]@JA Battle[/USER] says, normal HPTA operation requires frequent GnRH pulses. I did encounter some research showing that if there is a longer delay between pulses, e.g. one day, then the corresponding LH pulse is considerably larger. I don't believe this research was designed to see if single daily pulses would work indefinitely. The Royal trials are perhaps suggesting they do. I'd like to see some hard data on this. Basically he's imputing a very long half-life to whatever abstract process he's sketching on his timeline. I'd like to know if testicular volume would actually have this pattern—that is, be above the "active" line even with infrequent pulses. What about endogenous testosterone production? [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
Gonadorelin alternative to hCG - Kisspeptin a peptide that is not approved for compounding
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