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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
Gonadorelin alternative to hCG - Kisspeptin a peptide that is not approved for compounding
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<blockquote data-quote="JA Battle" data-source="post: 195167" data-attributes="member: 40068"><p>Frequent pulses are needed. Not infrequent pulses. 90-120 minutes roughly 15 micrograms I believe. The answer is infusion pump. Only problem is that if the pumps fail and deliver too much too consistently then you can desensitize gnrh receptors on pituitary and be unable of LH secretion. This may take a long time to correct itself if that happens.</p><p></p><p>Also this would work better for primary hypogonadal patients injecting testosterone and just creating LH for the sake of upstream hormone replacement. Secondary patients will benefit but it get tricky because if pump fails they will have low testosterone quickly without realizing it if they are using it as a sole testosterone replacement source. If pairing it with testosterone injection, then they will likely have too high a level of testosterone because they will be creating it endogenously and be administering it exogenously. Also it would require a enclomifene to be co administered to overcome negative feedback at the pituitary from exogenous testosterone. Possibly in primary patients dosed properly with testosterone or patients keeping e2 low enough one can omit the serm and still produce LH with GNRH pulsatile infusion. </p><p></p><p>we need to get a pump that works and pulses accurately and consistently and there are very few products in the world right now and I’ve tried to access them for 6 months but no luck.</p><p>we need to test this.</p></blockquote><p></p>
[QUOTE="JA Battle, post: 195167, member: 40068"] Frequent pulses are needed. Not infrequent pulses. 90-120 minutes roughly 15 micrograms I believe. The answer is infusion pump. Only problem is that if the pumps fail and deliver too much too consistently then you can desensitize gnrh receptors on pituitary and be unable of LH secretion. This may take a long time to correct itself if that happens. Also this would work better for primary hypogonadal patients injecting testosterone and just creating LH for the sake of upstream hormone replacement. Secondary patients will benefit but it get tricky because if pump fails they will have low testosterone quickly without realizing it if they are using it as a sole testosterone replacement source. If pairing it with testosterone injection, then they will likely have too high a level of testosterone because they will be creating it endogenously and be administering it exogenously. Also it would require a enclomifene to be co administered to overcome negative feedback at the pituitary from exogenous testosterone. Possibly in primary patients dosed properly with testosterone or patients keeping e2 low enough one can omit the serm and still produce LH with GNRH pulsatile infusion. we need to get a pump that works and pulses accurately and consistently and there are very few products in the world right now and I’ve tried to access them for 6 months but no luck. we need to test this. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
Gonadorelin alternative to hCG - Kisspeptin a peptide that is not approved for compounding
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