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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
Gonadorelin alternative to hCG - Kisspeptin a peptide that is not approved for compounding
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<blockquote data-quote="platypus5007" data-source="post: 195163" data-attributes="member: 41921"><p>Ok, got off a call with Royal. They say that the blood tests showing LH is maintained is due to exactly what [USER=38109]@Cataceous[/USER] presumed: Royal is running labs within 1-2 hours of injecting Gonadorelin. So of course it drops precipitously after that timeframe until the next injection in a couple days. The head doc commented that this is on purpose because constant stimulation actually leads to lower LH (possibly based on the studies above), whereas a pulse can provide symptom relief.</p><p></p><p>From the study on monkeys: "GnRH administration (50 micrograms) induced a 13- to 20-fold rise in serum LH and a 3- to 7-fold increase in serum T in control monkeys. After 4 weeks of Ag administration, none of the animals responded to GnRH."</p><p></p><p>I'm skeptical that the infrequent pulse is enough to prevent shrinkage, let alone maintain fertility. In fact, I think if maintaining fertility is a concern, you should be extremely skeptical and hesitant to jump on Gonadorelin as an alternative to hCG. Look at the negative effects on sperm on Gonadorelin and even many months post-treatment:</p><p></p><p>"The quality of semen samples taken from oligospermic monkeys was greatly reduced. The percentage of motile and percentage of live sperm per ejaculate, the net negative surface charge on sperm, and the scores of sperm in the hamster oocyte penetration test were subnormal." <a href="https://pubmed.ncbi.nlm.nih.gov/3316265/" target="_blank">Influence of simultaneous gonadotropin-releasing hormone agonist and testosterone treatment on spermatogenesis and potential fertilizing capacity in male monkeys - PubMed</a></p><p></p><p>I think, but don't want to accuse, that Royal is performing a sleight of hand by testing right after injection without disclosing that. If infrequent pulsing is the answer, we need more research and case studies following people undergoing treatment.</p></blockquote><p></p>
[QUOTE="platypus5007, post: 195163, member: 41921"] Ok, got off a call with Royal. They say that the blood tests showing LH is maintained is due to exactly what [USER=38109]@Cataceous[/USER] presumed: Royal is running labs within 1-2 hours of injecting Gonadorelin. So of course it drops precipitously after that timeframe until the next injection in a couple days. The head doc commented that this is on purpose because constant stimulation actually leads to lower LH (possibly based on the studies above), whereas a pulse can provide symptom relief. From the study on monkeys: "GnRH administration (50 micrograms) induced a 13- to 20-fold rise in serum LH and a 3- to 7-fold increase in serum T in control monkeys. After 4 weeks of Ag administration, none of the animals responded to GnRH." I'm skeptical that the infrequent pulse is enough to prevent shrinkage, let alone maintain fertility. In fact, I think if maintaining fertility is a concern, you should be extremely skeptical and hesitant to jump on Gonadorelin as an alternative to hCG. Look at the negative effects on sperm on Gonadorelin and even many months post-treatment: "The quality of semen samples taken from oligospermic monkeys was greatly reduced. The percentage of motile and percentage of live sperm per ejaculate, the net negative surface charge on sperm, and the scores of sperm in the hamster oocyte penetration test were subnormal." [URL='https://pubmed.ncbi.nlm.nih.gov/3316265/']Influence of simultaneous gonadotropin-releasing hormone agonist and testosterone treatment on spermatogenesis and potential fertilizing capacity in male monkeys - PubMed[/URL] I think, but don't want to accuse, that Royal is performing a sleight of hand by testing right after injection without disclosing that. If infrequent pulsing is the answer, we need more research and case studies following people undergoing treatment. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
Gonadorelin alternative to hCG - Kisspeptin a peptide that is not approved for compounding
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