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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
Gonadorelin alternative to hCG - Kisspeptin a peptide that is not approved for compounding
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<blockquote data-quote="Cataceous" data-source="post: 188880" data-attributes="member: 38109"><p>One minor correction: Gonadorelin is not just a GnRH analog; it is bioidentical GnRH. More significantly, and a more deserving target for [USER=13328]@Jason Sypolt[/USER]'s ire, is that the video participants seem to be accepting without question that gonadorelin is a simple hCG replacement. One nod to a little complexity is the observation that gonadorelin won't work if the source of one's hypogonadism is in the pituitary—or testicles—rather than the hypothalamus. I have not seen statements about which scenario is more prevalent. If I had to guess I would say that a hypothalamic origin is most common, but I could be wrong.</p><p></p><p>In any case, the superficial treatment in the video means there's no mention of the fact that GnRH is normally delivered in pulses, which are typically no more than a few hours apart. Nor is there mention of the existence of negative feedback from estrogens at the pituitary, which could potentially reduce the effectiveness of exogenous GnRH. I have more background information in these two posts:</p><p>[URL unfurl="true"]https://www.excelmale.com/forum/threads/is-gnrh-suppression-hurting-us.20407/post-169995[/URL]</p><p>[URL unfurl="true"]https://www.excelmale.com/forum/threads/pituitary-restart-while-on-trt-promising-initial-results-with-gnrh-plus-enclomiphene.20864/post-176010[/URL]</p></blockquote><p></p>
[QUOTE="Cataceous, post: 188880, member: 38109"] One minor correction: Gonadorelin is not just a GnRH analog; it is bioidentical GnRH. More significantly, and a more deserving target for [USER=13328]@Jason Sypolt[/USER]'s ire, is that the video participants seem to be accepting without question that gonadorelin is a simple hCG replacement. One nod to a little complexity is the observation that gonadorelin won't work if the source of one's hypogonadism is in the pituitary—or testicles—rather than the hypothalamus. I have not seen statements about which scenario is more prevalent. If I had to guess I would say that a hypothalamic origin is most common, but I could be wrong. In any case, the superficial treatment in the video means there's no mention of the fact that GnRH is normally delivered in pulses, which are typically no more than a few hours apart. Nor is there mention of the existence of negative feedback from estrogens at the pituitary, which could potentially reduce the effectiveness of exogenous GnRH. I have more background information in these two posts: [URL unfurl="true"]https://www.excelmale.com/forum/threads/is-gnrh-suppression-hurting-us.20407/post-169995[/URL] [URL unfurl="true"]https://www.excelmale.com/forum/threads/pituitary-restart-while-on-trt-promising-initial-results-with-gnrh-plus-enclomiphene.20864/post-176010[/URL] [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
Gonadorelin alternative to hCG - Kisspeptin a peptide that is not approved for compounding
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