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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
Gonadorelin alternative to hCG - Kisspeptin a peptide that is not approved for compounding
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<blockquote data-quote="Cataceous" data-source="post: 188214" data-attributes="member: 38109"><p>Please share these links so we can examine them on a case-by-case basis. If there are any on Excel Male itself then I must have missed them. There are countless research papers that might also be cited for saying that gonadorelin "works". It is one of the most natural ways to treat hypogonadism, albeit also one of the most complicated. While you're at it, cite the specific things I've written that you find so troubling.</p><p></p><p></p><p>And yet appropriate use of gonadorelin—with infusion pumps—probably delivers better results than traditional TRT. I've pointed out that insulin pump technology is making this form of treatment more and more practical. It may be the way of the future.</p><p></p><p></p><p>I have to question if you've even read my posts. I have expressed a great deal of skepticism about this use of gonadorelin.</p><p></p><p style="margin-left: 20px">"On the minus side, <strong>it's unclear if such infrequent pulses can activate the pituitary to begin with</strong>. It will be interesting to see. <strong>Also on the minus side, these doses are supraphysiological by a factor of 100 or so. Might there be side effects due to this?</strong>"[<a href="https://www.excelmale.com/forum/threads/gonadorelin.21781/post-187859" target="_blank">R</a>]</p> <p style="margin-left: 20px"></p> <p style="margin-left: 20px">"As monotherapy it is effective if delivered every couple hours or so with an infusion pump. As an adjunct to TRT it works if taken <a href="https://www.excelmale.com/forum/threads/pituitary-restart-while-on-trt-promising-initial-results-with-gnrh-plus-enclomiphene.20864/" target="_blank">six times a day along with a SERM</a>. <strong>Less rigorous protocols are questionable, particularly the ones saying to inject it only once a week."</strong>[<a href="https://www.excelmale.com/forum/threads/gonadorelin-to-replace-hcg-compounding-pharmacy-source.21782/post-187202" target="_blank">R</a>]</p> <p style="margin-left: 20px"></p> <p style="margin-left: 20px">"<strong>I'd first ask the clinic to provide references demonstrating that gonadorelin (GnRH) would be effective in your situation. If you're on TRT then it is questionable that you'd get acceptable results unless you inject multiple times daily and also use a SERM.</strong>"[<a href="https://www.excelmale.com/forum/threads/clinic-switched-to-gonadorelin-from-hcg-what-to-do.21517/post-184279" target="_blank">R</a>]</p> <p style="margin-left: 20px"></p> <p style="margin-left: 20px">"More practically, the TRT community needs to know whether or not less frequent GnRH injections can provide benefits beyond the production of gonadotropins. ... <strong>Anybody wanting to experiment should of course do it under a doctor's supervision.</strong>"[<a href="https://www.excelmale.com/forum/threads/pituitary-restart-while-on-trt-promising-initial-results-with-gnrh-plus-enclomiphene.20864/post-180159" target="_blank">R</a>]</p> <p style="margin-left: 20px"></p> <p style="margin-left: 20px">"...<strong>I don't want to create excessive expectations.</strong> The outcome of any particular protocol can be quite dependent on the individual, and all too often just when you think you've figured something out, things change."[<a href="https://www.excelmale.com/forum/threads/pituitary-restart-while-on-trt-promising-initial-results-with-gnrh-plus-enclomiphene.20864/post-181023" target="_blank">R</a>]</p> <p style="margin-left: 20px"></p><p>Earlier in the current thread even!</p><p></p><p style="margin-left: 20px">"Gonadorelin <a href="https://www.excelmale.com/forum/threads/pituitary-restart-while-on-trt-promising-initial-results.20864/post-176010" target="_blank">may work</a> with TRT—producing endogenous LH and FSH—if you add a SERM. <strong>But it's not clear if even daily injections would be enough.</strong>"[<a href="https://www.excelmale.com/forum/threads/gonadorelin-alternative-to-hcg-kisspeptin-a-peptide-that-is-not-approved-for-compounding.20969/post-177453" target="_blank">R</a>]</p> <p style="margin-left: 20px"></p> <p style="margin-left: 20px">"<strong>It's true that for most men on TRT these hormones are not practical replacements for hCG...</strong>"[<a href="https://www.excelmale.com/forum/threads/gonadorelin-alternative-to-hcg-kisspeptin-a-peptide-that-is-not-approved-for-compounding.20969/post-178122" target="_blank">R</a>]</p><p></p><p></p><p>One of those goals is to feel better, and though complicated, my current protocol accomplishes this beyond my expectations. Another goal is to learn more and share that knowledge. These goals are front and center, not lost from sight.</p></blockquote><p></p>
[QUOTE="Cataceous, post: 188214, member: 38109"] Please share these links so we can examine them on a case-by-case basis. If there are any on Excel Male itself then I must have missed them. There are countless research papers that might also be cited for saying that gonadorelin "works". It is one of the most natural ways to treat hypogonadism, albeit also one of the most complicated. While you're at it, cite the specific things I've written that you find so troubling. And yet appropriate use of gonadorelin—with infusion pumps—probably delivers better results than traditional TRT. I've pointed out that insulin pump technology is making this form of treatment more and more practical. It may be the way of the future. I have to question if you've even read my posts. I have expressed a great deal of skepticism about this use of gonadorelin. [INDENT]"On the minus side, [B]it's unclear if such infrequent pulses can activate the pituitary to begin with[/B]. It will be interesting to see. [B]Also on the minus side, these doses are supraphysiological by a factor of 100 or so. Might there be side effects due to this?[/B]"[[URL='https://www.excelmale.com/forum/threads/gonadorelin.21781/post-187859']R[/URL]][/INDENT] [INDENT][/INDENT] [INDENT]"As monotherapy it is effective if delivered every couple hours or so with an infusion pump. As an adjunct to TRT it works if taken [URL='https://www.excelmale.com/forum/threads/pituitary-restart-while-on-trt-promising-initial-results-with-gnrh-plus-enclomiphene.20864/']six times a day along with a SERM[/URL]. [B]Less rigorous protocols are questionable, particularly the ones saying to inject it only once a week."[/B][[URL='https://www.excelmale.com/forum/threads/gonadorelin-to-replace-hcg-compounding-pharmacy-source.21782/post-187202']R[/URL]][/INDENT] [INDENT][/INDENT] [INDENT]"[B]I'd first ask the clinic to provide references demonstrating that gonadorelin (GnRH) would be effective in your situation. If you're on TRT then it is questionable that you'd get acceptable results unless you inject multiple times daily and also use a SERM.[/B]"[[URL='https://www.excelmale.com/forum/threads/clinic-switched-to-gonadorelin-from-hcg-what-to-do.21517/post-184279']R[/URL]][/INDENT] [INDENT][/INDENT] [INDENT]"More practically, the TRT community needs to know whether or not less frequent GnRH injections can provide benefits beyond the production of gonadotropins. ... [B]Anybody wanting to experiment should of course do it under a doctor's supervision.[/B]"[[URL='https://www.excelmale.com/forum/threads/pituitary-restart-while-on-trt-promising-initial-results-with-gnrh-plus-enclomiphene.20864/post-180159']R[/URL]][/INDENT] [INDENT][/INDENT] [INDENT]"...[B]I don't want to create excessive expectations.[/B] The outcome of any particular protocol can be quite dependent on the individual, and all too often just when you think you've figured something out, things change."[[URL='https://www.excelmale.com/forum/threads/pituitary-restart-while-on-trt-promising-initial-results-with-gnrh-plus-enclomiphene.20864/post-181023']R[/URL]][/INDENT] [INDENT][/INDENT] Earlier in the current thread even! [INDENT]"Gonadorelin [URL='https://www.excelmale.com/forum/threads/pituitary-restart-while-on-trt-promising-initial-results.20864/post-176010']may work[/URL] with TRT—producing endogenous LH and FSH—if you add a SERM. [B]But it's not clear if even daily injections would be enough.[/B]"[[URL='https://www.excelmale.com/forum/threads/gonadorelin-alternative-to-hcg-kisspeptin-a-peptide-that-is-not-approved-for-compounding.20969/post-177453']R[/URL]][/INDENT] [INDENT][/INDENT] [INDENT]"[B]It's true that for most men on TRT these hormones are not practical replacements for hCG...[/B]"[[URL='https://www.excelmale.com/forum/threads/gonadorelin-alternative-to-hcg-kisspeptin-a-peptide-that-is-not-approved-for-compounding.20969/post-178122']R[/URL]][/INDENT] One of those goals is to feel better, and though complicated, my current protocol accomplishes this beyond my expectations. Another goal is to learn more and share that knowledge. These goals are front and center, not lost from sight. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
Gonadorelin alternative to hCG - Kisspeptin a peptide that is not approved for compounding
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