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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
Gonadorelin alternative to hCG - Kisspeptin a peptide that is not approved for compounding
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<blockquote data-quote="Cataceous" data-source="post: 178135" data-attributes="member: 38109"><p>There are numerous studies on using gonadorelin to successfully treat hypogonadotropic hypogonadism. I see no mention that the inter-dose interval is so critical. Probably every one to three hours is viable. In the <a href="https://www.excelmale.com/forum/threads/pituitary-restart-while-on-trt-promising-initial-results.20864/post-176010" target="_blank">trial I describe</a>, <strong>6 doses a day at roughly 3-hour intervals are producing some LH and a significant increase in testicular volume compared to hCG alone—while TRT is continued.</strong> Gonadorelin isn't commonly used because you need an infusion pump to do it right. Technological advances in insulin pumps may make this form of treatment more practical.</p><p></p><p style="margin-left: 20px"><em>The dose required to achieve an LH level equivalent to normal men were not different for 2 or 4-hour IPIs </em>[interpulse intervals] <em>and the dose required at the 1-hour IPI was greater than that required at the 4- or 8-hour IPI.</em></p><p>[URL unfurl="true"]https://www.researchgate.net/publication/5784170_Interplay_between_Dose_and_Frequency_of_GnRH_Administration_in_Determining_Pituitary_Gonadotropin_Responsiveness[/URL]</p><p></p><p>See also:</p><p>[URL unfurl="true"]https://journals.lww.com/md-journal/Fulltext/2019/08020/Optimal_treatment_for_spermatogenesis_in_male.25.aspx[/URL]</p></blockquote><p></p>
[QUOTE="Cataceous, post: 178135, member: 38109"] There are numerous studies on using gonadorelin to successfully treat hypogonadotropic hypogonadism. I see no mention that the inter-dose interval is so critical. Probably every one to three hours is viable. In the [URL='https://www.excelmale.com/forum/threads/pituitary-restart-while-on-trt-promising-initial-results.20864/post-176010']trial I describe[/URL], [B]6 doses a day at roughly 3-hour intervals are producing some LH and a significant increase in testicular volume compared to hCG alone—while TRT is continued.[/B] Gonadorelin isn't commonly used because you need an infusion pump to do it right. Technological advances in insulin pumps may make this form of treatment more practical. [INDENT][I]The dose required to achieve an LH level equivalent to normal men were not different for 2 or 4-hour IPIs [/I][interpulse intervals] [I]and the dose required at the 1-hour IPI was greater than that required at the 4- or 8-hour IPI.[/I][/INDENT] [URL unfurl="true"]https://www.researchgate.net/publication/5784170_Interplay_between_Dose_and_Frequency_of_GnRH_Administration_in_Determining_Pituitary_Gonadotropin_Responsiveness[/URL] See also: [URL unfurl="true"]https://journals.lww.com/md-journal/Fulltext/2019/08020/Optimal_treatment_for_spermatogenesis_in_male.25.aspx[/URL] [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
Gonadorelin alternative to hCG - Kisspeptin a peptide that is not approved for compounding
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