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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
Gonadorelin alternative to hCG - Kisspeptin a peptide that is not approved for compounding
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<blockquote data-quote="Cataceous" data-source="post: 177551" data-attributes="member: 38109"><p>To function normally the pituitary requires that GnRH be delivered in pulses. These are typically from one to three hours apart. The short half-life is actually a requirement. When exposed to GnRH continuously, the pituitary stops producing the gonadotropins, LH and FSH. There are long-lasting analogs of GnRH that are used to cause HPTA shutdown intentionally. These include triptorelin.</p><p></p><p>I'm less sure about what happens at the other extreme, with infrequent stimulation. Research has shown that after a period of normal stimulation, e.g. with a pulse every couple hours, the pituitary responds fairly normally to pulses that are eight hours apart. The study did not go on long enough to see if this would work indefinitely. </p><p></p><p>So there are at least two possible problems: there may be some limit to the relative infrequency of pituitary stimulation at which gonadotropin production drops. We know that after months of inactivity the pituitary usually does not initially respond to renewed GnRH pulses. Months are not a problem, but if it's only hours then it becomes impractical, requiring an infusion pump. The results to-date of the gonadorelin trial in the link above are ambiguous in this regard: there appear to be some subjective benefits in having even low levels of gonadotropins, around 1 mIU/mL. But this is with six injections a day; if there is not further improvement over time then things are much less promising for two injections a week.</p><p></p><p>That segues to the other question, which is whether single, infrequent pulses of the gonadotropins are sufficient to provide the desired benefits: prevention of testicular atrophy and other less tangible improvements, such as in libido, mood, etc.</p></blockquote><p></p>
[QUOTE="Cataceous, post: 177551, member: 38109"] To function normally the pituitary requires that GnRH be delivered in pulses. These are typically from one to three hours apart. The short half-life is actually a requirement. When exposed to GnRH continuously, the pituitary stops producing the gonadotropins, LH and FSH. There are long-lasting analogs of GnRH that are used to cause HPTA shutdown intentionally. These include triptorelin. I'm less sure about what happens at the other extreme, with infrequent stimulation. Research has shown that after a period of normal stimulation, e.g. with a pulse every couple hours, the pituitary responds fairly normally to pulses that are eight hours apart. The study did not go on long enough to see if this would work indefinitely. So there are at least two possible problems: there may be some limit to the relative infrequency of pituitary stimulation at which gonadotropin production drops. We know that after months of inactivity the pituitary usually does not initially respond to renewed GnRH pulses. Months are not a problem, but if it's only hours then it becomes impractical, requiring an infusion pump. The results to-date of the gonadorelin trial in the link above are ambiguous in this regard: there appear to be some subjective benefits in having even low levels of gonadotropins, around 1 mIU/mL. But this is with six injections a day; if there is not further improvement over time then things are much less promising for two injections a week. That segues to the other question, which is whether single, infrequent pulses of the gonadotropins are sufficient to provide the desired benefits: prevention of testicular atrophy and other less tangible improvements, such as in libido, mood, etc. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
Gonadorelin alternative to hCG - Kisspeptin a peptide that is not approved for compounding
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