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Testosterone Replacement, Low T, HCG, & Beyond
Blood Test Discussion
Gman's Test Prop Labs
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<blockquote data-quote="madman" data-source="post: 153256" data-attributes="member: 13851"><p>Unless you are one that falls in the 2% of Caucasians that genetically have one of the 2 SHBG polymorphisms which have been described to affect T:SHBG binding than highly doubtful!</p><p></p><p></p><p></p><p></p><p></p><p></p><p><strong><span style="color: rgb(0, 0, 0)">[0325]</span><span style="color: rgb(44, 130, 201)">*The current algorithm and the experimental data reported here were generated using wild type SHBG which is present in nearly 98% of Caucasians.</span></strong> <span style="color: rgb(184, 49, 47)"><strong>Genome wide association studies have revealed several SHBG polymorphisms, </strong></span><span style="color: rgb(147, 101, 184)"><strong>two of which have been reported to affect testosterone binding to SHBG (28).</strong></span> <span style="color: rgb(26, 188, 156)"><strong>Therefore, in future, the algorithms may include a term for the SHBG genotype. </strong></span></p><p></p><p></p><p></p><p></p><p></p><p><span style="color: rgb(44, 130, 201)"><strong>In summary, the experimental data of testosterone's association with SHBG implicate a complex allostery mechanism within the SHBG dimer. The new Multi-step Dynamic Binding Model with Complex Allostery provides excellent fit to the experimental data generated using three different techniques. </strong></span><span style="color: rgb(26, 188, 156)"><strong>Unlike the existing equations based on homogenous binding of testosterone with SHBG, which reveal systematic discrepancy from the values obtained by </strong></span><span style="color: rgb(251, 160, 38)"><strong>equilibrium dialysis, </strong></span><span style="color: rgb(44, 130, 201)"><strong>the free testosterone concentrations derived using the new model do not differ significantly from those measured using </strong></span><span style="color: rgb(251, 160, 38)"><strong>equilibrium dialysis. </strong></span></p></blockquote><p></p>
[QUOTE="madman, post: 153256, member: 13851"] Unless you are one that falls in the 2% of Caucasians that genetically have one of the 2 SHBG polymorphisms which have been described to affect T:SHBG binding than highly doubtful! [B][COLOR=rgb(0, 0, 0)][0325][/COLOR][COLOR=rgb(44, 130, 201)]*The current algorithm and the experimental data reported here were generated using wild type SHBG which is present in nearly 98% of Caucasians.[/COLOR][/B] [COLOR=rgb(184, 49, 47)][B]Genome wide association studies have revealed several SHBG polymorphisms, [/B][/COLOR][COLOR=rgb(147, 101, 184)][B]two of which have been reported to affect testosterone binding to SHBG (28).[/B][/COLOR][COLOR=rgb(184, 49, 47)][B] [/B][/COLOR][COLOR=rgb(26, 188, 156)][B]Therefore, in future, the algorithms may include a term for the SHBG genotype. [/B][/COLOR] [COLOR=rgb(44, 130, 201)][B]In summary, the experimental data of testosterone's association with SHBG implicate a complex allostery mechanism within the SHBG dimer. The new Multi-step Dynamic Binding Model with Complex Allostery provides excellent fit to the experimental data generated using three different techniques. [/B][/COLOR][COLOR=rgb(26, 188, 156)][B]Unlike the existing equations based on homogenous binding of testosterone with SHBG, which reveal systematic discrepancy from the values obtained by [/B][/COLOR][COLOR=rgb(251, 160, 38)][B]equilibrium dialysis, [/B][/COLOR][COLOR=rgb(44, 130, 201)][B]the free testosterone concentrations derived using the new model do not differ significantly from those measured using [/B][/COLOR][COLOR=rgb(251, 160, 38)][B]equilibrium dialysis. [/B][/COLOR] [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Blood Test Discussion
Gman's Test Prop Labs
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