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I used to take 12.5mg zolpidem (generic Ambien) manufactured by Lupin, India. The tablet is supposedly "slow release" but is not releasing the drug, unless I chew it and hold it in mouth 10 mins. Otherwise, it was not working at all.

FDA is interested only that the generic contains the main drug, nobody actually tests or controls the delivery vehicle. If you read reviews of psychotropic drugs, many people complaining that generics, mostly from India, do not work as the brand name drug.

That is the back side of getting generics from India - nontested and nonregulated drug delivery excipients, hampering the drug effectiveness.

[QUOTE="sammmy, post: 245628, member: 38594"] I used to take 12.5mg zolpidem (generic Ambien) manufactured by Lupin, India. The tablet is supposedly "slow release" but is not releasing the drug, unless I chew it and hold it in mouth 10 mins. Otherwise, it was not working at all. FDA is interested only that the generic contains the main drug, nobody actually tests or controls the delivery vehicle. If you read reviews of psychotropic drugs, many people complaining that generics, mostly from India, do not work as the brand name drug. That is the back side of getting generics from India - nontested and nonregulated drug delivery excipients, hampering the drug effectiveness. [/QUOTE]

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TRT Hormone Predictor Widget

Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038