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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Gene's Nitric Oxide Stack
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<blockquote data-quote="Gene Devine" data-source="post: 11172" data-attributes="member: 4"><p>This is why I like Horny Goat Weed in my NO stack.</p><p></p><p>Icariin is the active ingredient in Horny Goat Weed.</p><p></p><p>From examin.com:</p><p></p><p>[h=3]Interactions with Sexuality[/b][h=4]6.1. Erections[/b]Icariin is a selective PDE5 (enzyme) inhibitor<a href="http://examine.com/supplements/Horny+Goat+Weed/#ref37" target="_blank">[37]</a> with an IC50 value between 0.75-1.1mM depending on PDE5 isoform<a href="http://examine.com/supplements/Horny+Goat+Weed/#ref37" target="_blank">[37]</a> and an EC50 of about 4.62mmol/L in increasing cGMP in the corpus cavernosum of the penis;<a href="http://examine.com/supplements/Horny+Goat+Weed/#ref38" target="_blank">[38]</a> Icariin has approximately 100-fold greater affinity for PDE5 than other PDE isozymes.<a href="http://examine.com/supplements/Horny+Goat+Weed/#ref39" target="_blank">[39]</a> This effect can be potentiated by the modification of two hydroxyethyl ether moieties to the compound, which increase this inhibition 80-fold,<a href="http://examine.com/supplements/Horny+Goat+Weed/#ref40" target="_blank">[40]</a> but this modification is not naturally occurring. At 10mg/kg bodyweight in mice (110mg for a 150lb human) Icariin exerts pro-erectile properties<a href="http://examine.com/supplements/Horny+Goat+Weed/#ref36" target="_blank">[36]</a> and seems to have more effectiveness following repeated doses.<a href="http://examine.com/supplements/Horny+Goat+Weed/#ref35" target="_blank">[35]</a><a href="http://examine.com/supplements/Horny+Goat+Weed/#ref36" target="_blank">[36]</a> It has shown efficacy over 30 days at 5-10mg/kg in an animal model of erectile dysfunction related to blood flow,<a href="http://examine.com/supplements/Horny+Goat+Weed/#ref41" target="_blank">[41]</a> which correlates to a 55-110mg dose for a 150lb man.</p><p>Other compounds in the <em>Epimedium</em> family that have PDE5 inhibitory potential are Icarisid II derived from <em>Epimedium wanshanense</em> (not significantly different in potency than Icariin; approximately half of Viagra)<a href="http://examine.com/supplements/Horny+Goat+Weed/#ref42" target="_blank">[42]</a></p><p> Secondary to PDE5 inhibition, Icariin appears to be a potent pro-erectile agent. It is clearly outperformed by Viagra</p><p>Lower doses (1-5mg/kg) are able to improve neuronal Nitric Oxide Synthase (NOS) expression<a href="http://examine.com/supplements/Horny+Goat+Weed/#ref36" target="_blank">[36]</a> and inducible (iNOS) expression<a href="http://examine.com/supplements/Horny+Goat+Weed/#ref35" target="_blank">[35]</a><a href="http://examine.com/supplements/Horny+Goat+Weed/#ref36" target="_blank">[36]</a> content in addition to PDE5 inhibtion. Effects on iNOS and nNOS do not appear to differ greatly from each other at the dosages of 1mg, 5mg, and 10mg/kg bodyweight,<a href="http://examine.com/supplements/Horny+Goat+Weed/#ref36" target="_blank">[36]</a> suggesting low doses could also exert benefit but by different means.</p><p> Icariin may also promote <a href="http://examine.com/topics/Nitric+Oxide/" target="_blank">Nitric Oxide</a> signalling via increasing expression of NOS enzymes, which may work synergistically with the PDE5 inhibition</p><p>Icariin has also been linked to increasing neurite growth of major pelvic ganglia <em>in vitro</em><a href="http://examine.com/supplements/Horny+Goat+Weed/#ref36" target="_blank">[36]</a> which may be downstream of P13K and MEK/ERK activation.<a href="http://examine.com/supplements/Horny+Goat+Weed/#ref43" target="_blank">[43]</a></p></blockquote><p></p>
[QUOTE="Gene Devine, post: 11172, member: 4"] This is why I like Horny Goat Weed in my NO stack. Icariin is the active ingredient in Horny Goat Weed. From examin.com: [h=3]Interactions with Sexuality[/b][h=4]6.1. Erections[/b]Icariin is a selective PDE5 (enzyme) inhibitor[URL="http://examine.com/supplements/Horny+Goat+Weed/#ref37"][37][/URL] with an IC50 value between 0.75-1.1mM depending on PDE5 isoform[URL="http://examine.com/supplements/Horny+Goat+Weed/#ref37"][37][/URL] and an EC50 of about 4.62mmol/L in increasing cGMP in the corpus cavernosum of the penis;[URL="http://examine.com/supplements/Horny+Goat+Weed/#ref38"][38][/URL] Icariin has approximately 100-fold greater affinity for PDE5 than other PDE isozymes.[URL="http://examine.com/supplements/Horny+Goat+Weed/#ref39"][39][/URL] This effect can be potentiated by the modification of two hydroxyethyl ether moieties to the compound, which increase this inhibition 80-fold,[URL="http://examine.com/supplements/Horny+Goat+Weed/#ref40"][40][/URL] but this modification is not naturally occurring. At 10mg/kg bodyweight in mice (110mg for a 150lb human) Icariin exerts pro-erectile properties[URL="http://examine.com/supplements/Horny+Goat+Weed/#ref36"][36][/URL] and seems to have more effectiveness following repeated doses.[URL="http://examine.com/supplements/Horny+Goat+Weed/#ref35"][35][/URL][URL="http://examine.com/supplements/Horny+Goat+Weed/#ref36"][36][/URL] It has shown efficacy over 30 days at 5-10mg/kg in an animal model of erectile dysfunction related to blood flow,[URL="http://examine.com/supplements/Horny+Goat+Weed/#ref41"][41][/URL] which correlates to a 55-110mg dose for a 150lb man. Other compounds in the [I]Epimedium[/I] family that have PDE5 inhibitory potential are Icarisid II derived from [I]Epimedium wanshanense[/I] (not significantly different in potency than Icariin; approximately half of Viagra)[URL="http://examine.com/supplements/Horny+Goat+Weed/#ref42"][42][/URL] Secondary to PDE5 inhibition, Icariin appears to be a potent pro-erectile agent. It is clearly outperformed by Viagra Lower doses (1-5mg/kg) are able to improve neuronal Nitric Oxide Synthase (NOS) expression[URL="http://examine.com/supplements/Horny+Goat+Weed/#ref36"][36][/URL] and inducible (iNOS) expression[URL="http://examine.com/supplements/Horny+Goat+Weed/#ref35"][35][/URL][URL="http://examine.com/supplements/Horny+Goat+Weed/#ref36"][36][/URL] content in addition to PDE5 inhibtion. Effects on iNOS and nNOS do not appear to differ greatly from each other at the dosages of 1mg, 5mg, and 10mg/kg bodyweight,[URL="http://examine.com/supplements/Horny+Goat+Weed/#ref36"][36][/URL] suggesting low doses could also exert benefit but by different means. Icariin may also promote [URL="http://examine.com/topics/Nitric+Oxide/"]Nitric Oxide[/URL] signalling via increasing expression of NOS enzymes, which may work synergistically with the PDE5 inhibition Icariin has also been linked to increasing neurite growth of major pelvic ganglia [I]in vitro[/I][URL="http://examine.com/supplements/Horny+Goat+Weed/#ref36"][36][/URL] which may be downstream of P13K and MEK/ERK activation.[URL="http://examine.com/supplements/Horny+Goat+Weed/#ref43"][43][/URL] [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
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Gene's Nitric Oxide Stack
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