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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Gel or inject ?
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<blockquote data-quote="madman" data-source="post: 211230" data-attributes="member: 13851"><p><strong><em>*Natural testosterone is viewed as the best androgen for substitution in hypogonadal men. The reason behind the selection is that testosterone can be converted to DHT and E2, thus developing the full spectrum of testosterone activities in long-term substitution</em></strong></p><p><strong><em></em></strong></p><p><strong><em>*<strong><em>Diurnal variation in endogenous serum T levels in healthy men is well documented, with the highest T levels in the morning and lowest values in the afternoon and early evening, although the amplitudes of peak and trough levels vary by age</em></strong></em></strong></p><p><strong><em></em></strong></p><p><strong><em>*The ideal treatment for hypogonadism should provide physiological testosterone levels, exhibit appropriate circadian rhythms, and be modulated by the HPG axis. <u>No formulation of testosterone has been able to achieve this</u></em></strong></p><p></p><p><em><strong><strong>*The daily dosing frequency of the topical gel products results in a PK profile with a resemblance to that of endogenous T in younger males</strong></strong></em></p><p><em><strong></strong></em></p><p><em><strong>*<u>All IM TTh preparations</u> result in PK profiles that are unlike those of the normal diurnal variation of healthy young or older men</strong></em></p><p><em><strong></strong></em></p><p><em><strong><em><strong>*No single formulation appears to provide an exposure profile that would resemble diurnal variation of both young and older men</strong></em></strong></em></p></blockquote><p></p>
[QUOTE="madman, post: 211230, member: 13851"] [B][I]*Natural testosterone is viewed as the best androgen for substitution in hypogonadal men. The reason behind the selection is that testosterone can be converted to DHT and E2, thus developing the full spectrum of testosterone activities in long-term substitution *[B][I]Diurnal variation in endogenous serum T levels in healthy men is well documented, with the highest T levels in the morning and lowest values in the afternoon and early evening, although the amplitudes of peak and trough levels vary by age[/I][/B] *The ideal treatment for hypogonadism should provide physiological testosterone levels, exhibit appropriate circadian rhythms, and be modulated by the HPG axis. [U]No formulation of testosterone has been able to achieve this[/U][/I][/B] [I][B][B]*The daily dosing frequency of the topical gel products results in a PK profile with a resemblance to that of endogenous T in younger males[/B] *[U]All IM TTh preparations[/U] result in PK profiles that are unlike those of the normal diurnal variation of healthy young or older men [I][B]*No single formulation appears to provide an exposure profile that would resemble diurnal variation of both young and older men[/B][/I][/B][/I] [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Gel or inject ?
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