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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone and Men's Health Articles
Fundamental understanding of drug absorption from a parenteral oil depot
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<blockquote data-quote="madman" data-source="post: 190406" data-attributes="member: 13851"><p><strong>Fig. 1. <span style="color: rgb(184, 49, 47)">Schematic overview of the vivo situation </span><span style="color: rgb(0, 0, 0)">(left)</span><span style="color: rgb(184, 49, 47)">. </span><span style="color: rgb(44, 130, 201)">The equation on the right presents the parameters which contribute to the mole flux </span><span style="color: rgb(26, 188, 156)">(Φmole ″)</span>. <span style="color: rgb(26, 188, 156)">Abbreviations:</span> bulk concentration (pro) drug in oil <span style="color: rgb(26, 188, 156)">(Co b)</span>, at oil interface <span style="color: rgb(26, 188, 156)">(Co i)</span>, at tissue interface <span style="color: rgb(26, 188, 156)">(Ctissue i)</span>, in tissue beginning <span style="color: rgb(26, 188, 156)">(Ctissue,1)</span>, before entering central compartment <span style="color: rgb(26, 188, 156)">(Ctissue,2)</span> and in serum (Cserum); <span style="color: rgb(26, 188, 156)">d = </span>diffusion layer in oil <span style="color: rgb(26, 188, 156)">(d1)</span> and tissue fluid <span style="color: rgb(26, 188, 156)">(d2)</span>; <span style="color: rgb(26, 188, 156)">P =</span> partition coefficient; <span style="color: rgb(26, 188, 156)">D =</span> diffusion coefficient in oil <span style="color: rgb(26, 188, 156)">(Do)</span> and in tissue fluid <span style="color: rgb(26, 188, 156)">(Dtissue) </span></strong></p><p>[ATTACH=full]11546[/ATTACH]</p></blockquote><p></p>
[QUOTE="madman, post: 190406, member: 13851"] [B]Fig. 1. [COLOR=rgb(184, 49, 47)]Schematic overview of the vivo situation [/COLOR][COLOR=rgb(0, 0, 0)](left)[/COLOR][COLOR=rgb(184, 49, 47)]. [/COLOR][COLOR=rgb(44, 130, 201)]The equation on the right presents the parameters which contribute to the mole flux [/COLOR][COLOR=rgb(26, 188, 156)](Φmole ″)[/COLOR]. [COLOR=rgb(26, 188, 156)]Abbreviations:[/COLOR] bulk concentration (pro) drug in oil [COLOR=rgb(26, 188, 156)](Co b)[/COLOR], at oil interface [COLOR=rgb(26, 188, 156)](Co i)[/COLOR], at tissue interface [COLOR=rgb(26, 188, 156)](Ctissue i)[/COLOR], in tissue beginning [COLOR=rgb(26, 188, 156)](Ctissue,1)[/COLOR], before entering central compartment [COLOR=rgb(26, 188, 156)](Ctissue,2)[/COLOR] and in serum (Cserum); [COLOR=rgb(26, 188, 156)]d = [/COLOR]diffusion layer in oil [COLOR=rgb(26, 188, 156)](d1)[/COLOR] and tissue fluid [COLOR=rgb(26, 188, 156)](d2)[/COLOR]; [COLOR=rgb(26, 188, 156)]P =[/COLOR] partition coefficient; [COLOR=rgb(26, 188, 156)]D =[/COLOR] diffusion coefficient in oil [COLOR=rgb(26, 188, 156)](Do)[/COLOR] and in tissue fluid [COLOR=rgb(26, 188, 156)](Dtissue) [/COLOR][/B] [ATTACH type="full"]11546[/ATTACH] [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone and Men's Health Articles
Fundamental understanding of drug absorption from a parenteral oil depot
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